Fig. 4

Drug-pathway-target-disease network diagram and the distribution of core targets in the most related pathways. (a) Drug-pathway-target-disease network diagram illustrating the relationships among olanzapine, pathways, targets, and diseases to explain olanzapine’s effects on agitation in schizophrenia and bipolar disorder. Orange inverted triangles represent the drug olanzapine; diamonds represent the top 10 signaling pathways; blue circles indicate common targets enriched in these pathways; red diamonds and triangles denote core pathways and core targets, respectively; pink hexagons represent diseases; and yellow rounded rectangles represent the agitation symptoms. (b–c) Distribution of the eight common core targets in the PI3K/AKT and MAPK signaling pathways. The eight common core targets are BDNF, INS, AKT1, TP53, IGF1, NGF, NFKB1, and FGF2. Red symbols indicate enriched common targets; red ovals and arrows show the positions of the core targets within the pathways. (b) PI3K/AKT signaling pathway. (c) MAPK signaling pathway.