Table 1 Baseline characteristics of the discovery cohort according to the status of sarcopenia (144 men and 72 women).
From: Amino acid metabolites as potential circulating biomarkers for sarcopenia
Disease | Men (n = 144) | Women (n = 72) | ||||
|---|---|---|---|---|---|---|
Control (n = 72) | Sarcopenia (n = 72) | p | Control (n = 36) | Sarcopenia (n = 36) | p | |
Age (years) | 74.0 [72.0; 76.0] | 74.0 [72.0; 76.0] | 0.989 | 70.4 ± 5.8 | 70.3 ± 5.7 | 0.935 |
Weight (kg) | 72.7 [66.5; 79.5] | 56.2 [51.2; 59.1] | < 0.001 | 65.2 [62.2; 70.1] | 49.4 [46.0; 50.7] | < 0.001 |
Height (cm) | 167.8 ± 4.8 | 163.0 ± 5.1 | < 0.001 | 156.0 ± 3.9 | 151.7 ± 3.8 | < 0.001 |
BMI (kg/m2) | 26.1 [24.1; 27.9] | 21.1 [19.4; 22.6] | < 0.001 | 26.8 [25.1; 29.1] | 20.9 [19.7; 22.6] | < 0.001 |
Smoking, n (%) | 0.002 | 0.602 | ||||
Ex-smoker | 57 (79.2%) | 42 (58.3%) | 0 (0.0%) | 1 (2.8%) | ||
Non-smoker | 12 (16.7%) | 13 (18.1%) | 34 (94.4%) | 35 (97.2%) | ||
Current smoker | 3 (4.2%) | 17 (23.6%) | 1 (2.8%) | 1 (2.8%) | ||
Drinking, n (%) | 0.174 | 0.170 | ||||
No alcohol | 34 (47.2%) | 41 (56.9%) | 7 (19.4%) | 3 (8.3%) | ||
Alcohol < 1/week | 20 (27.8%) | 19 (26.4%) | 2 (5.6%) | 0 (0.0%) | ||
Alcohol 1‒2/week | 12 (16.7%) | 4 (5.6%) | 0 (0.0%) | 1 (2.8%) | ||
Alcohol ≥ 3/week | 6 (8.3%) | 8 (11.1%) | 27 (75.0%) | 32 (88.9%) | ||
Exercise, n (%) | 0.397 | 0.296 | ||||
No exercise | 6 (8.3%) | 12 (16.7%) | 4 (11.1%) | 4 (11.1%) | ||
Exercise < 1/week | 4 (5.6%) | 6 (8.3%) | 3 (8.3%) | 2 (5.6%) | ||
Exercise 1‒2/week | 12 (16.7%) | 10 (13.9%) | 7 (19.4%) | 2 (5.6%) | ||
Exercise ≥ 3/week | 50 (69.4%) | 44 (61.1%) | 22 (61.1%) | 28 (77.8%) | ||
Hypertension, n (%) | 50 (69.4%) | 37 (52.1%) | 0.051 | 24 (66.7%) | 14 (38.9%) | 0.034 |
Diabetes, n (%) | 60 (95.8%) | 64 (90.1%) | 0.314 | 29 (80.6%) | 29 (80.6%) | > 0.999 |
FM (kg) | 21.6 [16.9; 23.9] | 14.1 [11.2; 17.8] | < 0.001 | 25.5 [22.3; 28.6] | 16.6 [14.8; 18.6] | < 0.001 |
pFM (%) | 28.1 ± 6.2 | 25.0 ± 6.6 | 0.003 | 38.5 ± 5.3 | 33.3 ± 4.9 | < 0.001 |
SARC-F | 0.0 [0.0; 1.0] | 1.0 [0.0; 2.0] | 0.005 | 1.0 [0.0; 2.0] | 0.0 [0.0; 2.0] | 0.545 |
HGS (kg) | 34.6 ± 7.0 | 28.5 ± 5.6 | < 0.001 | 22.2 ± 5.1 | 20.8 ± 3.8 | 0.172 |
Chair stand up test (s) | 7.0 [6.0;9.0] | 7.0 [5.0;8.0] | 0.874 | 9.0 [7.0; 11.0] | 8.0 [6.0; 10.0] | 0.462 |
LM (kg) | 49.6 [47.7; 52.4] | 39.8 [38.0; 41.6] | < 0.001 | 39.1 [37.2; 41.3] | 30.8 [29.4; 32.0] | < 0.001 |
ASM (kg) | 22.4 [21.4; 23.9] | 16.9 [16.1; 18.2] | < 0.001 | 16.7 [15.8; 17.9] | 12.3 [11.4; 13.0] | < 0.001 |
SMI (kg/m2) | 8.0 [7.6; 8.4] | 6.5 [6.2; 6.6] | < 0.001 | 6.9 [6.6; 7.2] | 5.5 [5.0; 5.5] | < 0.001 |
