Table 3 Association between AA metabolite levels and HGS and SMI in the discovery cohort using univariate linear regression analysis (144 men and 72 women).

From: Amino acid metabolites as potential circulating biomarkers for sarcopenia

 

SMI

HGS

βa

SE

βb

p

βa

SE

βb

p

Men (n = 144)

Ile per 1SD

0.303

0.073

0.331

5.19E-05

1.353

0.577

0.193

0.021

Leu per 1SD

0.357

0.071

0.389

1.45E-06

1.681

0.240

0.571

0.004

Val per 1SD

0.335

0.072

0.366

6.55E-06

1.343

0.578

0.191

0.022

Met per 1SD

0.232

0.074

0.252

0.002

0.235

0.588

0.033

0.690

Phe per 1SD

0.237

0.074

0.259

0.002

0.293

0.588

0.042

0.619

Trp per 1SD

0.181

0.075

0.197

0.018

1.438

0.576

0.205

0.014

α-AAA per 1SD

0.284

0.073

0.309

1.62E-04

1.019

0.582

0.145

0.082

Glu per 1SD

0.281

0.073

0.306

1.90E-04

0.617

0.586

0.088

0.294

MetO per 1SD

0.226

0.075

0.257

0.003

0.235

0.588

0.033

0.690

Women (n = 72)

Glu per 1SD

0.324

0.106

0.344

0.003

0.728

0.530

0.162

0.174

  1. AA metabolite levels were log-transformed because of their skewed distribution.
  2. βa: Unstandardized coefficient, βb: Standardized coefficient.
  3. Abbreviations: AAs, amino acids; α-AAA, alpha-aminoadipic acid; Glu, Glutamate; HGS, hand grip strength; Ile, isoleucine; Leu, leucine; Met, methionine; MetO, methionine sulfoxide; Phe, phenylalanine; SD, standard deviation; SMI: skeletal muscle mass index; Trp, tryptophan; Val, valine.
  4. Bold numbers indicate statistically significant values.
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