Table 4 Association between AA metabolite levels and HGS and SMI in the discovery cohort males using multivariate linear regression analysis (144 men).

From: Amino acid metabolites as potential circulating biomarkers for sarcopenia

 

Univariate analysis

Multivariate analysis

βa

SE

βb

p

βa

SE

βb

p

SMI

Leu per 1SD

0.357

0.071

0.389

1.45E-06

0.307

0.071

0.335

3.01E-05

Glu per SD

0.281

0.073

0.306

1.90E-04

0.207

0.071

0.226

0.004

Phe per 1SD

0.237

0.074

0.259

0.002

    

Trp per 1SD

0.181

0.075

0.197

0.018

    

α-AAA per 1SD

0.284

0.073

0.309

1.62E-04

    

HGS

Leu per 1SD

1.681

0.571

0.240

0.004

1.681

0.571

0.240

0.004

Trp per 1SD

1.438

0.576

0.205

0.014

    
  1. AA metabolite levels were log-transformed because of their skewed distribution.
  2. Multivariate analysis was selected using backward elimination.
  3. βa: Unstandardized coefficient, βb: Standardized coefficient.
  4. Abbreviations: AAs, amino acids; Glu, glutamate; HGS, hand grip strength; Leu, leucine; SD, standard deviation; SMI: skeletal muscle mass index.
  5. Bold numbers indicate statistically significant values.
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