Fig. 3
Inflammatory cytokines were significantly decreased in the pendrin-KO mice group than those in pendrin-WT mice in the supine HTV group, analyzed using ELISA. (A) Tumor necrosis factor-α (TNF-α) levels were significantly reduced in pendrin-WT mice administered with YS-01 under HTV conditions. (B) Macrophage inflammatory protein (MIP-2) levels markedly decreased in both the pendrin-KO mice and pendrin-WT mice with YS-01 groups under supine HTV conditions. (C) Interleukin-1β (IL-1ß) levels elevated under HTV ventilation, but did not differ significantly among experimental groups. NVC, non-ventilation control group; supine HTV, HTV ventilation in supine position; prone HTV, HTV ventilation in prone position; HTV, high tidal volume; WT, wild-type; KO, knockout. *p < 0.05, **p < 0.01, ***p < 0.001 analyzed by Student’s unpaired two-tailed t-test.
