Fig. 6 | Scientific Reports

Fig. 6

From: Pendrin inhibition is associated with protective effect of prone positioning in a ventilator-induced lung injury mouse model

Fig. 6

Ventilator-induced lung injury model in mice. Pendrin wild-type (WT) and knockout (KO) mice were tracheostomized and ventilated in the supine or prone position with a high tidal volume (HTV) of 30 mL/kg and a rate of 100 breaths/min for 5 h. The other ventilator settings were 0.21 inspired oxygen fraction and 0 cm H2O end-expiratory pressure. Pendrin inhibitor (YS-01) or vesicle was administered intra-peritoneally 1 h before inducing VILI in the supine position.

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