Fig. 1 | Scientific Reports

Fig. 1

From: Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia

Fig. 1

Metabolic pathways involved in the mechanism of action of thiopurines. Abbreviations: 6-MP, 6-mercaptopurine; 6-Me-MP, 6-methyl-mercaptopurine; 6-Me-TG, 6-methyl-thioguanine; 6-Me-tIMP, 6-methyl-thioinosine-monophosphate; 6-Me-tITP, 6-methyl-thioinosine-triphosphate; 6-TG, thioguanine; 6-TGN, 6-thioguanine nucleotides; 6-tIDP, 6-thio-inosine diphosphate; 6-tIMP, 6-thio-inosine monophosphate; 6-tITP, 6-thio-inosine triphosphate; AZA, azathioprine; GMPS, guanosine monophosphatase synthetase; HGPRT, hypoxanthine guanine phosphoribosyl transferase; IMPDH, inosine monophosphate dehydrogenase; ITPA, inosine triphosphate pyrophosphatase; SAH, S-adenosyl-L-homocysteine; SAM, S-adenosyl-L-methionine; TPMT, thiopurine S-methyltransferase; XO, xanthine oxidase17.

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