Fig. 3 | Scientific Reports

Fig. 3

From: Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia

Fig. 3

The effect of the rs1884725 polymorphism in the XO gene on 6-MP treatment response in pediatric ALL. Effect of rs1884725 on 6-MP dose intensity in (a) and the frequency of APC reduction in (b). APC reduction refers to frequency of APC < 0.75 × 109 cells/L during the consolidation II and maintenance phases of the chemotherapy. Median values for GG (wild-type) and GA + AA (variant carriers) genotypes are presented next to the box plot, and the number of individuals is indicated at the top of the plots. The p-value for the difference between GG and GA + AA genotype, as obtained by Man-Whitney test, is shown.

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