Fig. 4

Metabolite changes in patients with thyroid cancer lymph node metastasis. Metabolite composition classification in Y2 and W2 (A). Volcano map of differentially expressed metabolites in Y2 and W2 (B). KEGG enrichment analysis and related DEMs (C). Differentially expressed metabolite bar graph in Y2 and W2. Horizontal coordinates are log2FC of differential metabolites and vertical coordinates are differential metabolites (D). ROC curve analysis of the candidate biomarkers shows the abundance of the five metabolites and high AUCs for the five metabolites (E). Y2: lymph node metastasis, W2: non- lymph node metastasis.