Table 3 Adjusted multivariable logistic regression model for ESRD, CVD and stroke adjusted for diabetes and hypertension diagnoses, ages, sex and albuminuria (Bold italic – statistical significance).

From: Comparative risk of end-stage renal disease, myocardial infarction and stroke in young and older onset diabetes in UK Biobank

Outcomes

Diabetes and hypertension status

Odds ratio

95% CI

p-value

ESRD

Diabetes

Diagnosis age < 20 vs. > 60 years

4.71

2.47 – 9.28

 < 0.001

Diagnosis age 20 – 40 vs. > 60 years

4.67

2.63 – 8.78

 < 0.001

Diagnosis age 41 – 60 vs. > 60 years

1.94

1.16 – 3.49

0.017

Male vs. female

0.91

0.66 – 1.29

0.605

Microalbuminuria vs. normoalbuminuria

3.15

2.09 – 4.86

 < 0.001

Macroalbuminuria vs. normoalbuminuria

25.03

16.73 – 38.41

 < 0.001

Hypertension

Diagnosis age < 20 vs. > 60 years

2.51

1.68 – 3.83

 < 0.001

Diagnosis age 20 – 40 vs. > 60 years

4.69

3.31 – 6.86

 < 0.001

Diagnosis age 41 – 60 vs. > 60 years

1.49

1.06 – 2.16

0.029

Male vs. female

1.23

1.03 – 1.47

0.024

Microalbuminuria vs. normoalbuminuria

3.87

3.14 – 4.77

 < 0.001

Macroalbuminuria vs. normoalbuminuria

35.65

28.74 – 44.36

 < 0.001

Myocardial infarction

Diabetes

Diagnosis age < 20 vs. 20 – 40 years

1.14

0.84 – 1.52

0.393

Diagnosis age 41—60 vs. 20 – 40 years

0.72

0.72 – 1.08

0.226

Diagnosis age > 60 vs. 20 – 40 years

1.05

0.84 – 1.33

0.649

Male vs. female

2.95

2.50 – 3.49

 < 0.001

Microalbuminuria vs. normoalbuminuria

1.24

1.09 – 1.41

 < 0.001

Macroalbuminuria vs. normoalbuminuria

1.42

1.14 – 1.76

 < 0.001

Hypertension

Diagnosis age < 20 vs. > 60 years

1.87

1.58 – 2.23

 < 0.001

Diagnosis age 20 – 40 vs. > 60 years

1.30

1.10 – 1.53

0.001

Diagnosis age 41 – 60 vs. > 60 years

1.34

1.18 – 1.54

 < 0.001

Male vs. female

3.78

1.32 – 1.56

 < 0.001

Microalbuminuria vs. normoalbuminuria

1.44

1.32 – 1.56

 < 0.001

Macroalbuminuria vs. normoalbuminuria

2.00

1.70 – 2.36

 < 0.001

Angina

Diabetes

Diagnosis age < 20 vs. 41 – 60 years

1.15

0.88 – 1.47

0.291

Diagnosis age 20 – 40 vs. 41 – 60 years

0.92

0.73 – 1.15

0.484

Diagnosis age > 60 vs. 41 – 60 years

1.12

0.95 – 1.31

0.168

Male vs. female

1.13

0.98 – 1.31

0.085

Microalbuminuria vs. normoalbuminuria

1.06

0.93 – 1.21

0.373

Macroalbuminuria vs. normoalbuminuria

1.47

1.16 – 1.83

 < 0.001

Hypertension

Diagnosis age < 20 vs. 41 – 60 years

1.13

1.00 – 1.29

0.052

Diagnosis age 20 – 40 vs. 41 – 60 years

0.98

0.88 – 1.10

0.796

Diagnosis age > 60 vs. 41 – 60 years

1.02

0.90 – 1.14

0.793

Male vs. female

1.39

1.28 – 1.51

 < 0.001

Microalbuminuria vs. normoalbuminuria

1.12

1.03 – 1.22

0.008

Macroalbuminuria vs. normoalbuminuria

1.80

1.51 – 2.12

 < 0.001

Stroke

Diabetes

Diagnosis age < 20 vs. 41 – 60 years

1.22

0.83 – 1.73

0.287

Diagnosis age 20 – 40 vs. 41 – 60 years

1.02

0.73 – 1.40

0.880

Diagnosis age > 60 vs. 41 – 60 years

1.01

0.78 – 1.28

0.944

Male vs female

0.96

0.78 – 1.18

0.675

Microalbuminuria vs. normoalbuminuria

1.06

0.87 – 1.29

0.561

Macroalbuminuria vs. normoalbuminuria

1.28

0.89 – 1.79

0.164

Hypertension

Diagnosis age < 20 vs. 41 – 60 years

1.12

0.94 – 1.33

0.200

Diagnosis age 20 – 40 vs. 41 – 60 years

0.92

0.79 – 1.08

0.323

Diagnosis age > 60 vs. 41 – 60 years

1.02

0.86 – 1.19

0.808

Male vs female

1.26

1.13 – 1.47

 < 0.001

Microalbuminuria vs. normoalbuminuria

1.31

1.17 – 1.47

 < 0.001

Macroalbuminuria vs. normoalbuminuria

1.68

1.30 – 2.12

 < 0.001

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