Fig. 12
From: Macrophage mitophagy-related genes predict prognosis and therapeutic response in lung adenocarcinoma
Functional enrichment and immune checkpoint analysis. (A) Violin plots comparing TMB between HRG and LRG, suggesting a link to immunogenicity and tumor aggressiveness. (B) Distribution of cytolytic activity (CYT) scores across RiskScore groups, with elevated CYT in high-risk patients indicative of enhanced immune activation. (C) Violin plots depicting differences in tertiary lymphoid structure (TLS) scores, reflecting heterogeneity in adaptive immune responses. (D) Expression analysis of immune checkpoint genes revealed lower BTLA and CD47 expression in high-risk patients, suggesting potential responsiveness to immunotherapy. (E) GO and KEGG pathway enrichment analysis of hub genes highlighting roles in oxidative stress, immune signaling, and mitophagy. (F) GSEA results showing differential activation of immune-related and metabolic pathways between HRG and LRG.
