Fig. 5
From: Macrophage mitophagy-related genes predict prognosis and therapeutic response in lung adenocarcinoma
Expression and prognostic significance of hub genes. (A) t-SNE plots illustrating the spatial expression distribution of the hub genes across various cell types in the LUAD tumor microenvironment, highlighting their potential cellular specificity and functional relevance. (B) Pseudotime heatmaps showing dynamic expression changes of hub genes during cell state transitions, indicating their involvement in lineage differentiation and fate decisions. (C) Bar plots comparing the expression levels of hub genes between LUAD tissues and adjacent normal tissues based on TCGA data. (D) Network plots showing differential expression of hub genes across tumor and normal tissues in 33 TCGA cancer types. (E) Heatmap depicting the connection between hub gene expression and immune cell infiltration levels across 33 cancer types in TCGA. (F) Prognostic heatmap analyzing the connection between hub gene expression and overall survival across pan-cancer datasets. (G) Forest plot of M-Cox analysis for hub genes across 33 cancers in the TCGA dataset.
