Fig. 4
From: Restoring apoptosis in breast cancer via peptide mediated disruption of survivin IAP interaction
Molecular docking analysis of cIAP1 and NAIP with Survivin. Docking results indicate that cIAP1 and NAIP interact with the linker region of Survivin, similar to XIAP. Specifically, cIAP1 engages via its BIR1 and BIR2 domains, whereas NAIP interacts through the BIR1, BIR3, and NACHT domains. (a) Binding interactions of the BIR1 domain of cIAP1 with Survivin. (b) Binding interactions of the BIR2 domain of cIAP1 with Survivin. (c) Binding interactions of the BIR3 domain of cIAP1 with Survivin. (d) Binding interactions of the CARD domain of cIAP1 with Survivin. (e) Binding interactions of the RING domain of cIAP1 with Survivin. (f) Binding interactions of full-length cIAP1 with Survivin. (g) Binding interactions of full-length NAIP with Survivin.
