Fig. 6
From: Restoring apoptosis in breast cancer via peptide mediated disruption of survivin IAP interaction
Root Mean Square Deviation (RMSD) analysis of Survivin–cIAP1 and Survivin–NAIP systems. RMSD values of the systems and protein backbones were calculated during molecular dynamics (MD) simulations at different time points. The RMSD plots show that both the cIAP1–Survivin and NAIP–Survivin systems exhibit fluctuation patterns similar to those of their crystal structures before simulation, as well as to the individual proteins. This indicates that the cIAP1–Survivin and NAIP-Survivin interactions remain stable throughout the simulations. (a) RMSD Xtal values of the cIAP1–Survivin system. (b) RMSD Xtal values of the NAIP–Survivin system. (c)RMSD values of the cIAP1–Survivin system. (d) RMSD values of the NAIP–Survivin system. (e) RMSD values of the cIAP1 protein. (f) RMSD values of the NAIP protein.
