Fig. 2 | Scientific Reports

Fig. 2

From: NSC23766 effectively inhibited retinal neovascularization by disrupting the positive feedback loop between Rac1 and VEGFR2

Fig. 2

Effects of NSC23766 on GTP-Rac1 Expression in HRMECs with or without VEGF Stimulation. (A) Changes in GTP-Rac1 (activated Rac1) expression in HRMECs following VEGF stimulation (20 ng/mL) at different time points, and the inhibitory effect of NSC23766 on GTP-Rac1 levels under VEGF (50 ng/mL) stimulation (original blots are presented in Supplementary Material 1). (B) Quantification of GTP-Rac1 band intensity by Western blotting. (C) Quantification of Total-Rac1 band intensity by Western blotting. All values are displayed as mean ± SEM. ns: no significant difference, ***: P < 0.001, ****: P < 0.0001, unpaired t test between two groups; one-way ANOVA for more than two groups.

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