Fig. 5 | Scientific Reports

Fig. 5

From: NSC23766 effectively inhibited retinal neovascularization by disrupting the positive feedback loop between Rac1 and VEGFR2

Fig. 5

NSC23766 suppressed VEGF165-induced phosphorylation of VEGFR2 (Y1175) in HRMECs. (A) the Western blotting assays test the protein expression of p-VEGFR2 (Y1175), VEGFR2 and β-actin in HRMECs after treatment with VEGF165 (20 ng/mL) for 10 min and NSC23766 (200 µmol/mL) (original blots are presented in Supplementary Material 1). (B) Quantification and statistical analysis of Western blot band intensities for p-VEGFR2/total VEGFR2 ratio are shown in B. Data are presented as mean ± SEM. *: P < 0.05, **: P < 0.01, ****: P < 0.0001, multiple-group comparisons were analyzed by one-way ANOVA.

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