Table 3 List of adverse events of any grade.
Adverse event | Any grade | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
Asthenia | 76 (74%) | 61 (60%) | 15 (15%) | - | - |
Increased alanine aminotransferase level | 66 (65%) | 59 (58%) | 7 (7%) | - | - |
Increased aspartate aminotransferase level | 56 (55%) | 54 (53%) | 2 (2%) | - | - |
Peripheral neuropathy | 42 (41%) | 20 (20%) | 16 (16%) | 6 (6%) | - |
Nausea | 41 (40%) | 39 (38%) | 2 (2%) | - | - |
Arthralgia | 35 (34%) | 29 (28%) | 4 (4%) | 2 (2%) | - |
Myalgia | 33 (32%) | 28 (27%) | 3 (3%) | 2 (2%) | - |
Thrombopenia | 33 (32%) | 28 (27%) | 5 (5%) | - | - |
Neutropenia | 30 (30%) | 10 (10%) | 18 (18%) | 2 (2%) | - |
Headache | 28 (27%) | 26 (25%) | 2 (2%) | - | - |
Epistaxis | 26 (26%) | 25 (25%) | 1 (1%) | - | - |
Constipation | 25 (25%) | 22 (22%) | 3 (3%) | - | - |
Cutaneous and mucosal dryness | 20 (20%) | 20 (20%) | - | - | - |
Anemia | 20 (20%) | 18 (18%) | 2 (2%) | - | - |
Epigastralgia | 18 (18%) | 18 (18%) | - | - | - |
Diarrhea | 13 (13%) | 11 (11%) | 2 (2%) | - | - |
Mucitis | 12 (12%) | 11 (11%) | 1 (1%) | - | - |
Dysgeusia | 8 (8%) | 8 (8%) | - | - | - |
Gingivorrhagia | 6 (6%) | 5 (5%) | 1 (1%) | - | - |
Abdominal pain | 3 (3%) | 3 (3%) | - | - | - |
Hyperbilirubinemia | 3 (3%) | 3 (3%) | - | - | - |
Decreased Left Ventricular Ejection Fraction | 2 (2%) | - | 2 (2%) | - | - |
Rhinitis | 2 (2%) | 2 (2%) | - | - | - |
Infusion Related Reaction | 2 (2%) | 1 (1%) | 1 (1%) | - | - |
Pneumopathy | 1 (1%) | - | 1 (1%) | - | - |
