Fig. 8 | Scientific Reports

Fig. 8

From: GADD45β inhibits hepatic lipogenesis through the AMPK/SREBP1 pathway via reducing the ubiquitination-mediated degradation of SIRT1

Fig. 8

Working model of GADD45β in the regulation of hepatic steatosis. GADD45β expression is decreased in hepatocytes fed an MCD diet. A decrease in GADD45β does not interact with Sirtuin 1 (SIRT1) and is subsequently degraded by ubiquitination. This results in increased lipogenesis and thereby synergistically aggravates fatty acid accumulation and hepatic steatosis.

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