Fig. 2 | Scientific Reports

Fig. 2

From: Polyethylene microplastics disrupt renal function, mitochondrial bioenergetics, redox homeostasis, and histoarchitecture in Wistar rats

Fig. 2

Renal tricarboxylic cycle (TCA) enzyme activities in rats exposed to polyethylene microplastics (PE-MPs) at varying doses (15 and 60 mg/kg bw). Bar graphs represent mean ± SEM (n = 5/group) for a citrate synthase (CS), b isocitrate dehydrogenase (IDH), c malate dehydrogenase (MDH), and d succinate dehydrogenase (SDH) activities in renal tissue. PE-MPs exposure (15 and 60 mg/kg bw) significantly suppressed all four enzyme activities relative to control (*p < 0.05 to ***p < 0.001), indicating impaired TCA cycle flux and mitochondrial dysfunction. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test.

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