Table 2 Comparative ROC analysis of combined and individual Indicators.
Indicator | AUC(95%CI) | Cut-off Value | Sensitivity (%) | Specificity (%) | Youden Index | PPV | NPV |
|---|---|---|---|---|---|---|---|
CTCs alone | 0.85(0.78–0.92) | ≥ 28 | 84.4% | 79.3% | 0.637 | 68.2% | 90.1% |
TFD alone | 0.72(0.63–0.81) | ≤ 5.7 mm | 71.9% | 68.1% | 0.400 | 54.8% | 82.4% |
CTCs + TFD (Combined) | 0.91(0.86–0.96) | ≥ 28, ≤ 5.7 mm | 90.6% | 84.5% | 0.751 | 76.3% | 94.7% |