Fig. 1

T cell profiles in lung tissues of NSCLC patients with or without COPD. (A) The ratios of PD-1⁺ T cells in the CD4⁺ or CD8⁺ T cells of NIC or TIC were compared between NSCLC patients with or without COPD. (B) The ratios of Tim-3⁺ cells in the CD4⁺ and CD8⁺ T cells of NIC or TIC were compared between NSCLC patients with or without COPD. Data represent the mean ± standard error of the mean (SEM). The Mann–Whitney U test was used to analyze the significance of differences between samples. The p-value < 0.05 was considered to be significant. NIC, non-tumor infiltrating cells; TIC, tumor-infiltrating cells.