Table 1 Comparison of baseline demographic and laboratory data with 3-Month Follow-Up data for each studied group in H pylori positive patients.

From: Vonoprazan attenuates proteinuria in diabetic kidney disease through potential direct renal mechanism

 

Vonoprazan (50 patients)

 

Lansoprazole (50 patients)

p value

Age (Independent t test)

Mean ± SD

53.46 ± 11.55

 

53.02 ± 10.27

0.841

Range

30–79

 

34–77

Sex, N (%) (Chi square)

Male

27(54)

 

27(54)

1

Female

23(46)

 

23(46)

 
 

Baseline

3months follow up

 

Baseline

3months follow up

 
 

Median(IQR)

Range

Median(IQR)

Range

p value

Median(IQR)

Range

Median(IQR)

Range

p value

BMI

27(26–29)

22–36

27(25–30)

22–36

0.275

27(26–28)

24–33

27(26–28)

24–34

0.276

SBP

130(120–135)

110–155

130(120–135)

100–150

0.478

130(125–135)

120–170

130(125–135)

120–150

0.394

DBP

80(70–85)

60–100

80(70–90)

60–100

0.541

75(70–80)

70–110

80(75–90)

60–100

0.312

creatinine

1.7(1.5–1.8)

1.3–2.3

1.6(1.4–1.8)

1.2–2.3

< 0.001

1.7(1.6–1.8)

1.5–1.9

1.7(1.6–1.8)

1.4–1.9

0.288

Total protein

7(6.8–7.2)

5.9–7.9

7(6.9–7.1)

6–7.7.7

0.752

7(6.9–7.3)

6.2–8.2

7(7–7.2.2)

6.4–8.4

0.74

Albumin

4.1(3.9–4.3)

3.5–4.9

4(4–4.2.2)

3.4–4.9

0.934

4(3.8–4.1)

3.3–4.7

4(3.9–4.1)

3.3–4.8

0.099

ACR

1188(800–1369)

600–2735

819.5(512–987)

237–1951

< 0.001

1120(877–1333)

600–3345

984(785–1211)

314–3211

< 0.001

FBS

129(122–143)

100–198

122.5(113–130)

100–143

< 0.001

140(125–166)

120–199

133.5(125–154)

113–177

0.006

2hpp Blood sugar

165.5(145–189)

56–276

145.5(130–160)

34–201

< 0.001

168.5(155–211)

133–297

158.5(144–176)

124–220

< 0.001

HbA1c

7.2(7.1–7.5)

6.5–8.3

7.1(7–7.3.3)

6.5–7.9

< 0.001

7.1(7–7.5.5)

6.5–8.3

7.1(7–7.3.3)

6.4–8.4

0.032

GFR

42.5(38–47)

31–63

44.5(39–51)

30–82

< 0.001

43.5(35–50)

30–62

43.5(37–50)

31–66

0.482

Response to treatment: Stool H. pylori antigen after eradication therapy

Negative N (%)

36(72)

28(56)

0.096

Positive N (%)

14(28)

22(44)

  1. Wilcoxon test is the test of significance p value significant if ≤ 0.05.
  2. BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; TP = serum total protein; Alb = serum albumin; ACR = Albumin creatinine ratio; FBG = fasting blood sugar; 2hppBG = 2 h post prandial blood sugar.