Fig. 1

Baseline characteristics of PNET patients. (A) The cohort of 25 patients had a median age of 65 years, with 68% male and 32% female, and predominantly well-differentiated tumors. Tumors were most frequently located in the tail of the pancreas, with a median size of 2.0 cm, and a median overall survival of 60 months. (B) Logarithmic curve depicting overall survival in the PNET cohort. The graph demonstrates that survival the initial diagnosis was relatively stable for the first 60 months. Beyond 60 months, survival rates experienced a sharp decline, with majority of patients not surviving beyond 7.5 years. (C) Representative H&E-stained slides of surgically resected PNET specimens were analyzed to confirm pathology, differentiate tumor from benign tissue, and determine tumor grade. Samples include adjacent benign tissue, Grade 1 nonfunctional (NF) tumors, Grade 1 functional tumors, Grade 2 tumors, and their corresponding adjacent benign tissues. Insets in each panel highlight the morphological abnormalities characteristic of each tissue type. Scale bars represent 50 μm.