Fig. 2

DNMT1 is overexpressed in PNETs. (A–U) Representative IHC Staining immune markers including DNMT1, DNMT3A, DNMT3B, 5-HMC, MEN1, RASSF1, PTEN, in adjacent benign, Grade 1, and Grade 2 tissue sections, respectively. Scale bars represent 50 μm. (V) Bar graph depicting abovementioned percentages of upregulation/downregulation of each marker, with Standard of Error plotted. (W) Box and whisker plot showing the range and median of density scores determined using the Mann-Whitney U test. The boxes represent the interquartile range (IQR), with whiskers extending to the minimum and maximum values within 1.5 × IQR. The horizontal line within each box indicates the median. Statistical significance is stratified by tumor versus benign groups. Statistical significance is denoted as follows: *p < 0.05, **p < 0.01 ***p < 0.001, and “ns” indicates not statistically significant. (X) Box and whisker plot showing the range and median of density scores determined using the Mann-Whitney U test. The boxes represent the interquartile range (IQR), with whiskers extending to the minimum and maximum values within 1.5 × IQR. The horizontal line within each box indicates the median. Statistical significance is stratified by Grade 1 versus Grade 2 groups. Statistical significance is denoted as follows: *p < 0.05, **p < 0.01 ***p < 0.001, and “ns” indicates not statistically significant.