Fig. 2 | Scientific Reports

Fig. 2

From: Discovery and validation of proliferative exhausted T cells as a favorable prognostic biomarker in esophageal squamous cell carcinoma

Fig. 2

Single-cell atlas of ESCC cohort (GSE160269). (A) UMAP visualization of the 208,125 cells (64 ESCC samples: 60 tumor and 4 normal), colored by cell type. (B) Dot plot of the expression of marker genes for cell types defined in (A). Dot size corresponds to the percentage of cells expressing the marker gene, and dot color indicates the average expression. (C) Feature plot illustrating the distribution of selected marker genes of T cells. (D) Box plot of cell-type fractions identified in tumor and normal tissues, values are presented as mean ± SD. (E) UMAP visualization of T cells, colored by cell type. (F) Distribution of T cell cycle phases (G1, S, and G2/M). (G) Dot plot illustrating the expression levels and percentage of cells expressing selected T cell function-associated genes across different T cell clusters. (H) Kernel density estimation plot showing the distribution of MKI67 and CDK4 gene expression of T cells. (I) Infiltration scores of T cell subtypes between tumor and normal samples in the TCGA-ESCC dataset. (J) Survival analysis stratifying ESCC patients by T cell infiltration scores in the TCGA-ESCC dataset.

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