Table 2 Relationship between CXCL8 expression and clinicopathological features in PTC.

From: Identification of CXCL8 as a potential gene associated with lymph node metastasis in papillary thyroid carcinoma through bioinformatics analysis

Clinicopathological Feature

n

CXCL8-High, n (%)

CXCL8-Low, n (%)

χ²

P-value

Odds Ratio(95% Confidence Interval)

Gender

      

Male

10

8 (80.0)

2 (20.0)

–

1.000

1.20 (0.21–6.78)

Female

39

30 (76.9)

9 (23.1)

  

1.00 (reference)

Age (years), Median [IQR]

49

48 [38–57]

52 [45–61]

 

0.191

-

Tumor diameter (cm)

   

0.416

0.901

 

≤ 1

18

14 (77.8)

4 (22.2)

  

-

> 1 and ≤ 2

23

17 (73.9)

6 (26.1)

  

-

> 2 and ≤ 4

8

7 (87.5)

1 (12.5)

  

-

> 4

0

0 (0.0)

0 (0.0)

  

-

Tumor location

   

–

0.899

 

Left lobe

18

13 (72.2)

5 (27.8)

  

1.00 (reference)

Right lobe

17

14 (82.4)

3 (17.6)

  

1.79 (0.41–7.81)

Bilateral

12

9 (75.0)

3 (25.0)

  

1.15 (0.25–5.26)

Isthmus

2

2 (100.0)

0 (0.0)

  

-

Recurrence risk stratification

   

3.523

0.171

 

Low risk

25

17 (68.0)

8 (32.0)

  

1.00 (reference)

Moderate risk

24

21 (87.5)

3 (12.5)

  

3.29 (0.83–13.03)

High risk

0

0 (0.0)

0 (0.0)

  

-

Capsular invasion

   

2.194

0.138

 

No

26

18 (69.2)

8 (30.8)

  

1.00 (reference)

Yes

23

20 (87.0)

3 (13.0)

  

2.96 (0.74–11.82)

Extrathyroidal extension

   

2.667

0.102

 

No

25

17 (68.0)

8 (32.0)

  

1.00 (reference)

Yes

24

21 (87.5)

3 (12.5)

  

3.29 (0.83–13.03)

Hashimoto’s thyroiditis

   

–

0.006

 

No

39

34 (87.2)

5 (12.8)

  

1.00 (reference)

Yes

10

4 (40.0)

6 (60.0)

  

0.10 (0.03–0.36)

Multifocality

   

–

0.047

 

No

47

38 (80.9)

9 (19.1)

  

1.00 (reference)

Yes

2

0 (0.0)

2 (100.0)

  

0.00 (0.00–0.88)

Lymph Node Status

      

N0

23

12 (52.2)

11 (47.8)

–

1.00 (reference)

1.00 (reference)

N1a (Central only)

15

15 (100.0)

0 (0.0)

–

< 0.001

–

N1b (Lateral ± Central)

11

11 (100.0)

0 (0.0)

–

< 0.001

–

  1. Footnotes: (a) Total samples: n = 49. CXCL8 expression was dichotomized into High and Low groups based on the median IHC score. (b) No missing data were encountered for any variable. (c) For comparisons with any expected cell count < 5, Fisher’s exact test was applied. (d) For 2 × 2 tables with complete separation (e.g., N1a, N1b: 100% vs. 0%), the two-sided Fisher’s exact test was used. Effect sizes (OR) were estimated using Firth logistic regression (or Haldane–Anscombe 0.5 correction). (e) Extreme P-values are reported as P < 0.001. (f) The Chi-squared test was applied for other comparisons; Yates’ correction was not used. (g) Age is presented as median [IQR] due to the loss of information from dichotomization.
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