Table 2 Values of IC50 [µM] ± SEM and selectivity indices (SI) for SFN and its fluorescent derivatives in cancer cells of prostate (PC3) and breast (T47D), and normal cells (HDFa) based on MTT test after 24 h of treatment.
From: New fluorescently labeled isothiocyanate derivatives as a potential cancer theranostic tool
Compound | IC50 [µM] | SI | |||
|---|---|---|---|---|---|
PC3 | T47D | HDFa | PC3 | T47D | |
SFN | 33.5 ± 1.5 | 30.4 ± 1.9 | 49.8 ± 2.1 | 1.49 | 1.64 |
NBDC4NCS | 3.3 ± 0.2 | 2.8 ± 0.1 | 7.6 ± 0.6 | 2.30 | 2.71 |
MeAkrC4NCS | 4.0 ± 0.3 | 2.1 ± 0.1 | 7.1 ± 0.2 | 1.77 | 3.38 |
DNSC4NCS | 16.8 ± 0.8 | 21.1 ± 1.0 | 28.4 ± 1.4 | 1.69 | 1.35 |
AkrC4NCS | 30.6 ± 6.3 | 9.6 ± 1.2 | 91.9 ± 6.9 | 3.00 | 9.57 |
NBDC6NCS | 1.0 ± 0.1 | 1.2 ± 0.1 | 5.8 ± 0.5 | 5.8 | 4.83 |
