Table 1 Baseline characteristics of the patients (IQR).

From: A nomogram to predict submucosal fibrosis in early gastric cancer undergoing endoscopic submucosal dissection

Variable

Whole cohort (n = 264)

Training cohort (n = 184)

Validation cohort (n = 80)

χ2/Z statistic

P value

Sex, n (%)

   

1.961

0.161

Male

162 (61.36)

118 (64.13)

44 (55.00)

  

Female

102 (38.64)

66 (35.87)

36 (45.00)

  

Age (years)

62.00 (56.00 ~ 68.00)

62.00 (55.25 ~ 68.00)

64.50 (59.00 ~ 68.00)

-1.340

0.180

Comorbidities, n (%)

   

0.803

0.370

Yes

41 (15.53)

31 (16.85)

10 (12.50)

  

No

223 (84.47)

153 (83.15)

70 (87.50)

  

Antithrombotic drugs use, n (%)

   

0.032

0.857

Yes

21 (7.95)

15 (8.15)

6 (7.50)

  

No

243 (92.05)

169 (91.85)

74 (92.50)

  

Location, n (%)

   

1.274

0.529

Upper

62 (23.48)

40 (21.74)

22 (27.50)

  

Middle

68 (25.76)

50 (27.17)

18 (22.50)

  

Lower

134 (50.76)

94 (51.09)

40 (50.00)

  

Tumor size, n (%)

   

0.475

0.491

< 30 mm

211 (79.92)

145 (78.80)

66 (82.50)

  

≥ 30 mm

53 (20.08)

39 (21.20)

14 (17.50)

  

Macroscopic type, n (%)

   

0.154

0.695

Non-depressed

147 (55.68)

101 (54.89)

46 (57.50)

  

0-I

25 (9.47)

17 (9.24)

8 (10.00)

  

0-IIa

63 (23.86)

44 (23.91)

19 (23.75)

  

0-IIb

59 (22.35)

40 (21.74)

19 (23.75)

  

Depressed

117 (44.32)

83 (45.11)

34 (42.50)

  

0-IIc

76 (28.79)

53 (28.80)

23 (28.75)

  

0-III

41 (15.53)

30 (16.31)

11 (13.75)

  

Converging folds, n (%)

   

0.156

0.693

Yes

26 (9.85)

19 (10.33)

7 (8.75)

  

No

238 (90.15)

165 (89.67)

73 (91.25)

  

Ulcer scars, n (%)

   

0.219

0.640

Yes

37 (14.02)

27 (14.67)

10 (12.50)

  

No

227 (85.98)

157 (85.33)

70 (87.50)

  

Differentiation, n (%)

    

0.564*

Differentiated

249 (94.32)

172 (93.48)

77 (96.25)

  

Undifferentiated

15 (5.68)

12 (6.52)

3 (3.75)

  

Depth of invasion, n (%)

   

1.744

0.187

Mucosa

230 (87.12)

157 (85.33)

73 (91.25)

  

Submucosa

34 (12.88)

27 (14.67)

7 (8.75)

  

Lymphovascular invasion, n (%)

    

0.071*

Yes

14 (5.30)

13 (7.07)

1 (1.25)

  

No

250 (94.70)

171 (92.93)

79 (98.75)

  

Endoscopic submucosal fibrosis, n (%)

   

4.188

0.123

No (F0)

170 (64.39)

117 (63.59)

53 (66.25)

  

Mild (F1)

58 (21.97)

37 (20.11)

21 (26.25)

  

Severe (F2)

36 (13.64)

30 (16.30)

6 (7.50)

  

Histologic submucosal fibrosis, n (%)

   

1.359

0.507

No (f0)

164 (62.12)

112 (60.87)

52 (65.00)

  

Mild (f1)

60 (22.73)

41 (22.28)

19 (23.75)

  

Severe (f2)

40 (15.15)

31 (16.85)

9 (11.25)

  

En bloc resection, n (%)

   

0.007

0.934

Yes

247 (93.56)

172 (93.48)

75 (93.75)

  

No

17 (6.44)

12 (6.52)

5 (6.25)

  

Curative resection, n (%)

   

2.399

0.121

Yes

244 (92.42)

167 (90.76)

77 (96.25)

  

No

20 (7.58)

17 (9.24)

3 (3.75)

  

Procedure time (minute)

50.00 (40.00 ~ 80.00)

50.00 (36.25 ~ 100.00)

50.00 (40.00 ~ 80.00)

-0.819

0.413

Complications, n (%)

    

0.357*

No

235 (89.01)

160 (86.96)

75 (93.75)

  

Immediate bleeding

21 (7.95)

18 (9.78)

3 (3.75)

  

Delayed bleeding

4 (1.52)

3 (1.63)

1 (1.25)

  

Perforation

4 (1.52)

3 (1.63)

1 (1.25)

  
  1. Comorbidities include cardiovascular diseases, renal diseases, diabetes, and liver cirrhosis. Antithrombotic drugs use includes anticoagulant and antiplatelet drugs.
  2. *Fisher’s exact test. IQR: interquartile range.