Fig. 3

Venn diagram showing the numbers of annotated metabolites that differed across the four groups of glucose metabolism at baseline, that were changed during the one-year intervention period, and/or whose one-year changes correlated with a one-year change in 120-min glucose. Box plots show the baseline and one-year plasma levels of selected metabolites that were statistically significant in all these three statistical analyses in the four groups of glucose metabolism at baseline. Box plots of all the 55 metabolites impacted by the intervention are presented in Supplemental Figure S6. NGT: normal glucose tolerance, IGT: isolated impaired glucose tolerance, IGT + IFG: impaired glucose tolerance with increased fasting glucose, T2D: type 2 diabetes.