Table 6 A total of 584 differentially expressed genes (DEGs) were identified in the jejunum between resistant and susceptible animals (FDR < 0.05 and log2fold change > 2).

From: Differential gene expression analysis of Dohne Merino sheep naturally infected with Haemonchus contortus

 

Gene symbol

Gene Names

log2FoldChange

P-value

Downregulated

SEBOX

SEBOX homeobox

− 21,78

2,5E−08

 

A4GNT

alpha-1,4-N-acetylglucosaminyltransferase

− 21,78

2,5E−08

 

TMEM245

transmembrane protein 245

− 21,76

2,6E−08

 

HIP1

huntingtin interacting protein 1

− 21,73

2,7E−08

 

LOC105605798

ankyrin repeat domain-containing protein 26-like

− 21,72

2,8E−08

 

C4BPA

complement component 4 binding protein alpha

− 21,70

2,8E−08

 

TMEM43

transmembrane protein 43

− 21,66

3,1E−08

 

RAB11FIP3

RAB11 family interacting protein 3

− 21,66

3,1E−08

 

HELZ

helicase with zinc finger

− 14,24

4,4E−10

 

LOC101103517

butyrophilin subfamily 1 member A1-like

− 14,13

1,5E−11

 

LOC101109633

dihydrodiol dehydrogenase 3-like

− 13,83

5,5E−21

 

TRNAW-CCA

transfer RNA tryptophan (anticodon CCA)

− 13,00

1,9E−07

 

STK17A

serine/threonine kinase 17a

− 12,60

1,6E−04

 

MYO5B

myosin VB

− 12,21

1,8E−05

 

LOC105604103

uncharacterized LOC105604103

− 11,96

3,7E−06

 

RPRD1B

regulation of nuclear pre-mRNA domain containing 1B

− 11,92

3,5E−04

 

DENND1B

DENN domain containing 1B

− 11,92

4,6E−04

 

MPC1

mitochondrial pyruvate carrier 1

− 11,50

3,9E−04

 

SLC1A5

solute carrier family 1 member 5

− 11,33

4,2E−04

 

LOC105613145

40S ribosomal protein S26-like

− 11,28

7,8E−04

 

USP6NL

USP6 N-terminal like

− 10,97

9,7E−04

 

SMPD3

sphingomyelin phosphodiesterase 3

− 10,86

6,4E−04

 

IFT140

intraflagellar transport 140

− 10,85

6,7E−04

 

KIF1B

kinesin family member 1B

− 10,74

6,8E−04

 

RTP3

receptor transporter protein 3

− 10,59

8,2E−17

 

CERS5

ceramide synthase 5

− 10,49

2,2E−06

 

FABP1

fatty acid binding protein 1

− 10,47

2,1E−10

 

CD40LG

CD40 ligand

− 10,34

9,6E−04

 

SFTPD

surfactant protein D

− 10,28

3,1E−06

 

S100G

S100 calcium binding protein G

− 10,22

8,4E−07

 

C2H9orf3

chromosome 2 open reading frame, human C9orf3

− 10,20

1,2E−08

 

LCT

lactase

− 10,04

1,3E−09

 

SHISA4

shisa family member 4

− 9,88

3,7E−04

 

ZFPL1

zinc finger protein like 1

− 9,72

2,9E−14

 

HOMEZ

homeobox and leucine zipper encoding

− 9,70

6,6E−07

 

F13B

coagulation factor XIII B chain

− 9,61

1,3E−12

 

LOC101112888

zinc finger protein 782

− 9,50

4,6E−13

 

GFBP6

 

− 9,44

2,5E−05

 

PIH1D1

PIH1 domain containing 1

− 9,08

2,8E−06

 

NMRAL1

NmrA like redox sensor 1

− 9,06

1,3E−07

 

MFGE8

milk fat globule− EGF factor 8 protein

− 8,97

9,6E−21

 

SV2A

synaptic vesicle glycoprotein 2A

− 8,89

1,1E−07

 

LOC105609920

uncharacterized LOC105609920

− 8,80

6,2E−08

 

ADORA2B

adenosine A2b receptor

− 8,73

3,4E−04

 

ACOT9

acyl-CoA thioesterase 9

− 8,64

1,6E−04

 

GNG4

G protein subunit gamma 4

− 8,51

1,6E−06

 

ARL14EP

ADP ribosylation factor like GTPase 14 effector protein

− 8,51

8,4E−04

 

ZNF688

zinc finger protein 688

− 8,51

5,0E−04

 

UNC13B

unc-13 homolog B

− 8,41

1,2E−04

 

CELSR3

cadherin EGF LAG seven− pass G-type receptor 3

− 8,33

2,2E−09

 

HTR2B

5-hydroxytryptamine receptor 2B

− 8,26

8,0E−08

 

BARX2

BARX homeobox 2

-8,22

1,4E−05

 

TRNAG-UCC

transfer RNA glycine (anticodon UCC)

− 8,21

3,6E−06

 

SPECC1L

sperm antigen with calponin homology and coiled-coil domains 1 like

− 8,20

3,8E−04

 

LOC101115441

cytochrome P450 2C21-like

− 8,19

1,9E−09

 

CDSN

corneodesmosin

− 8,12

6,1E−08

 

LOC101108297

conglutinin-like

− 8,10

3,2E−05

 

RFC1

replication factor C subunit 1

− 8,05

5,0E−05

 

EP400

E1A binding protein p400

− 7,83

2,4E−07

 

EXTL3

exostosin like glycosyltransferase 3

− 7,80

3,3E−04

 

RBP5

retinol binding protein 5

− 7,73

3,9E−05

 

ALDH8A1

aldehyde dehydrogenase 8 family member A1

− 7,68

4,1E−05

 

LOC105614265

SLAM family member 5-like

− 7,65

4,1E−06

 

PITX1

paired like homeodomain 1

− 7,48

1,3E−06

 

LOC105604103

uncharacterized LOC105604103

− 7,41

7,6E−08

 

SOCS7

suppressor of cytokine signaling 7

− 7,35

1,2E−04

 

MOB1B

MOB kinase activator 1B

− 7,33

8,5E−04

 

TREH

trehalase

− 7,32

3,7E−11

 

CD19

CD19 molecule

− 7,21

2,5E−07

 

PARG

poly (ADP-ribose) glycohydrolase

− 7,18

1,3E−04

 

PSORS1C2

psoriasis susceptibility 1 candidate 2

− 7,07

4,0E−07

 

LRCOL1

leucine rich colipase like 1

− 7,06

8,4E−05

 

MED9

mediator complex subunit 9

− 7,01

4,2E−05

 

HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2

− 6,91

6,8E−05

 

CYP2C19

cytochrome P450 2C19

− 6,90

5,5E−06

 

SVIP

small VCP interacting protein

− 6,81

6,2E−05

 

SLC10A4

solute carrier family 10 member 4

− 6,77

3,0E−05

 

CREBRF

CREB3 regulatory factor

− 6,59

1,0E−04

 

ACSBG2

acyl-CoA synthetase bubblegum family member 2

− 6,58

4,1E−05

 

TAAR1

trace amine associated receptor 1

− 6,58

1,8E−04

 

TJP2

tight junction protein 2

− 6,49

7,5E−05

 

SUGCT

succinyl-CoA: glutarate-CoA transferase

− 6,47

2,7E−27

 

PHLDB3

pleckstrin homology like domain family B member 3

− 6,47

1,2E−12

 

LOC101107486

cytochrome P450 2C31-like

− 6,46

8,3E−06

 

SLC9A3

solute carrier family 9 member A3

− 6,45

3,9E−07

 

LOC105609073

mitochondrial import inner membrane translocase subunit Tim8 A pseudogene

− 6,44

7,0E−05

 

GPR68

G protein-coupled receptor 68

− 6,44

1,1E−04

 

UVRAG

UV radiation resistance associated

− 6,40

4,4E−04

 

LOC105603314

non-classical arabinogalactan protein 31-like

− 6,36

1,9E−04

 

LOC105613071

uncharacterized LOC105613071

− 6,35

5,5E−04

 

LOC105604756

uncharacterized LOC105604756

− 6,16

3,8E−05

 

LOC105609965

uncharacterized LOC105609965

− 6,09

4,6E−04

 

SEH1L

SEH1-like (S. cerevisiae)

− 6,06

1,3E−05

 

MRGPRF

MAS related GPR family member F

− 6,04

2,7E−04

 

ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

− 5,98

4,5E−06

 

INTS5

integrator complex subunit 5

− 5,94

7,4E−04

 

RRP9

ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)

− 5,92

1,7E−04

 

LAMP1

lysosomal associated membrane protein 1

− 5,91

2,1E−04

 

FANK1

fibronectin type III and ankyrin repeat domains 1

− 5,86

2,2E−04

 

MCCC2

methylcrotonoyl-CoA carboxylase 2

− 5,85

2,0E−04

 

DEDD2

death effector domain containing 2

− 5,76

2,8E−04

 

DNASE2

deoxyribonuclease 2, lysosomal

− 5,73

7,2E−04

 

RBM48

RNA binding motif protein 48

− 5,69

4,8E−04

 

ZMIZ2

zinc finger MIZ-type containing 2

− 5,67

4,2E−04

 

TMEM198

transmembrane protein 198

− 5,62

4,7E−04

 

ONECUT2

one cut homeobox 2

− 5,59

1,1E−18

 

COLEC11

collectin subfamily member 11

− 5,49

6,8E−04

 

APOC2

apolipoprotein C2

− 5,47

3,5E−05

 

LOC101119765

39S ribosomal protein L15, mitochondrial

− 5,46

1,5E−05

 

SLC35D3

solute carrier family 35 member D3

− 5,43

1,0E−03

 

APOC3

apolipoprotein C3

− 5,40

1,5E−04

 

CD58

CD58 molecule

− 5,21

4,5E−06

 

RAB8B

RAB8B, member RAS oncogene family

− 5,18

9,4E−15

 

CEND1

cell cycle exit and neuronal differentiation 1

− 5,17

2,2E−08

 

PRDM16

PR/SET domain 16

− 5,12

5,3E−06

 

AGXT2

alanine–glyoxylate aminotransferase 2

− 5,11

2,0E−04

 

FAM180A

family with sequence similarity 180 member A

− 5,10

9,0E−04

 

NPRL2

NPR2-like, GATOR1 complex subunit

− 5,07

5,0E−05

 

ACADS

acyl-CoA dehydrogenase, C− 2 to C-3 short chain

− 5,03

1,4E−17

 

GSTA1

microsomal glutathione-S-transferase 1–1

− 5,01

9,1E−07

 

LOC105616873

uncharacterized LOC105616873

− 4,93

3,5E−06

 

RTN3

reticulon 3

− 4,80

7,6E−04

 

TRNAW-CCA

transfer RNA tryptophan (anticodon CCA)

− 4,77

8,6E−04

 

LOC105604969

uncharacterized LOC105604969

− 4,66

4,1E−04

 

THNSL1

threonine synthase like 1

− 4,47

1,4E−04

 

GET4

Golgi to ER traffic protein 4

− 4,46

3,4E−05

 

CLASP2

cytoplasmic linker associated protein 2

− 4,41

6,7E−05

 

TRNAE−UUC

transfer RNA glutamic acid (anticodon UUC)

− 4,39

8,1E−04

 

LOC101120103

bile salt sulfotransferase-like

− 4,31

2,6E−05

 

EIF1

eukaryotic translation initiation factor 1

− 4,27

5,8E−04

 

IGFLR1

IGF like family receptor 1

− 4,25

9,3E−05

 

KLHDC3

kelch domain containing 3

− 4,06

4,9E−07

 

HPN

hepsin

− 4,03

2,1E−10

 

ANAPC2

anaphase promoting complex subunit 2

− 4,01

2,4E−05

 

LNX1

ligand of numb-protein X 1

− 3,97

2,6E−05

 

TRNAS-GGA

transfer RNA serine (anticodon GGA)

− 3,97

1,1E−05

 

PLIN1

perilipin 1

− 3,92

9,7E−04

 

TUBB4A

tubulin beta 4A class Iva

− 3,89

2,7E−14

 

PCBP4

poly(rC) binding protein 4

− 3,89

2,7E−08

 

DHRS1

dehydrogenase/reductase 1

− 3,78

8,8E−06

 

PROX1

prospero homeobox 1

− 3,67

1,5E−05

 

TSEN54

tRNA splicing endonuclease subunit 54

− 3,65

7,8E−08

 

TIMP4

TIMP metallopeptidase inhibitor 4

− 3,65

1,3E−07

 

LOC105604063

uncharacterized LOC105604063

− 3,63

3,8E−05

 

IGSF6

immunoglobulin superfamily member 6

− 3,60

1,1E−16

 

OSGEP

O− sialoglycoprotein endopeptidase

− 3,59

9,0E−05

 

MATN4

matrilin 4

− 3,58

9,7E−07

 

EARS2

glutamyl-tRNA synthetase 2, mitochondrial

− 3,57

2,3E−05

 

ANGPTL3

angiopoietin like 3

− 3,57

9,6E−05

 

HAPLN4

hyaluronan and proteoglycan link protein 4

− 3,49

5,7E−05

 

SPTBN5

spectrin beta, non-erythrocytic 5

− 3,37

8,4E−04

 

DDX3X

DEAD− box helicase 3, X-linked

− 3,35

1,5E−09

 

CLDN11

claudin 11

− 3,32

7,9E−04

 

CYP3A24

cytochrome P450 CYP3A24

− 3,32

3,0E−06

 

PEX11A

peroxisomal biogenesis factor 11 alpha

− 3,31

1,5E−08

 

MAP3K19

mitogen− activated protein kinase kinase kinase 19

− 3,28

1,1E−04

 

TM4SF5

transmembrane 4 L six family member 5

− 3,21

2,0E−04

 

SLC46A1

solute carrier family 46 member 1

− 3,19

2,5E−16

 

APOBEC3Z1

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like

− 3,17

3,5E−06

 

GSTA1-1

microsomal glutathione-S-transferase 1–1

− 3,15

3,4E−05

 

GIF

gastric intrinsic factor

− 3,12

4,7E−05

 

LOC101108580

F-box/LRR-repeat protein 6

− 3,12

1,9E−07

 

LOC101118415

metalloreductase STEAP1

− 3,06

4,0E−07

 

CRYBB1

crystallin beta B1

− 3,04

5,9E−05

 

SMIM6

small integral membrane protein 6

− 3,03

4,5E−08

 

CHP2

calcineurin like EF-hand protein 2

− 2,99

9,8E−14

 

CATSPERG

cation channel sperm associated auxiliary subunit gamma

− 2,82

1,8E−11

 

LOC105614551

interferon-inducible GTPase 1-like

− 2,71

6,2E−05

 

LOC101118415

metalloreductase STEAP1

− 2,69

8,2E−05

 

SDR42E2

short chain dehydrogenase/reductase family 42E, member 2

− 2,64

8,5E−07

 

LOC101104661

growth-regulated alpha protein

− 2,59

2,6E−04

 

SLC27A2

solute carrier family 27 member 2

− 2,55

1,2E−12

 

TPRKB

TP53RK binding protein

− 2,50

3,5E−05

 

WDR55

WD repeat domain 55

− 2,48

3,7E−10

 

LOC101118441

phylloquinone omega-hydroxylase CYP4F2

− 2,43

3,6E−05

 

LOC101119842

bile salt sulfotransferase-like

− 2,42

1,6E−08

 

CSRNP3

cysteine and serine rich nuclear protein 3

− 2,40

6,4E−05

 

LOC105603639

plectin-like

− 2,32

3,0E−04

 

LATS1

large tumor suppressor kinase 1

− 2,27

5,5E−04

 

LOC101120052

sperm-specific antigen 2

− 2,25

6,1E−08

 

MCTS1

MCTS1, re-initiation and release factor

− 2,22

1,9E−05

 

INSIG1

insulin induced gene 1

− 2,22

4,7E−08

 

ARHGEF11

Rho guanine nucleotide exchange factor 11

− 2,21

4,9E−05

 

PIGR

polymeric immunoglobulin receptor

− 2,20

2,0E−16

 

LOC101104046

thiamine transporter 2-like

− 2,19

8,6E−05

 

BPGM

bisphosphoglycerate mutase

− 2,10

4,0E−12

 

LOC101107541

dihydrodiol dehydrogenase 3-like

− 2,07

4,4E−06

 

LOC105605770

apolipoprotein L3-like

− 2,06

4,4E−04

 

PPARG

peroxisome proliferator-activated receptor gamma

− 2,01

8,4E−05

Upregulated

CPA3

carboxypeptidase A3

2,01

4,6E−04

 

NCF2

neutrophil cytosolic factor 2

2,02

1,1E−06

 

SEMA3G

semaphorin 3G

2,05

3,1E−04

 

LOC101117600

C-type lectin domain family 10 member A

2,06

8,7E−04

 

MBOAT1

membrane bound O-acyltransferase domain containing 1

2,07

2,4E−10

 

RNF152

ring finger protein 152

2,10

8,8E−09

 

CXCL9

C-X-C motif chemokine ligand 9

2,13

1,0E−20

 

FAR2

fatty acyl-CoA reductase 2

2,13

1,2E−04

 

LOC101119517

guanylate-binding protein 1-like

2,14

1,0E−04

 

P2RY13

purinergic receptor P2Y13

2,19

4,5E−04

 

LOC105602100

leukocyte immunoglobulin-like receptor subfamily B member 3

2,21

1,2E−04

 

ANAPC4

anaphase promoting complex subunit 4

2,21

8,0E−04

 

BDH1

3-hydroxybutyrate dehydrogenase, type 1

2,21

2,0E−04

 

LOC101103343

carcinoembryonic antigen-related cell adhesion molecule 6

2,25

8,5E−06

 

NCF1

neutrophil cytosolic factor 1

2,31

1,9E−06

 

CCDC85C

coiled-coil domain containing 85C

2,33

1,3E−06

 

LOC105611487

uncharacterized LOC105611487

2,36

2,1E−04

 

PRKX

protein kinase, X-linked

2,39

6,7E−05

 

GBP5

guanylate binding protein 5

2,53

2,4E−04

 

NDUFAF2

NADH: ubiquinone oxidoreductase complex assembly factor 2

2,53

1,3E−04

 

LOC101105481

guanylate-binding protein 1-like

2,53

7,7E−04

 

ACKR4

atypical chemokine receptor 4

2,60

3,4E−05

 

CXCR2

C-X-C motif chemokine receptor 2

2,62

4,9E−04

 

CLEC4A

C-type lectin domain family 4 member A

2,70

4,0E−05

 

C1H1orf162

chromosome 1 open reading frame, human C1orf162

2,74

8,5E−05

 

SLC51B

solute carrier family 51 beta subunit

2,76

1,6E−07

 

LOC106990526

uncharacterized LOC106990526

2,83

6,8E−04

 

CXCL11

C-X-C motif chemokine ligand 11

2,88

1,5E−06

 

CDK10

cyclin dependent kinase 10

2,92

3,9E−05

 

PLSCR1

phospholipid scramblase 1

3,06

8,0E−08

 

LOC105608442

serine/threonine-protein kinase LMTK3-like

3,06

3,6E−04

 

SHC4

SHC adaptor protein 4

3,07

9,1E−08

 

PCBD2

pterin-4 alpha-carbinolamine dehydratase 2

3,07

1,5E−06

 

DPEP1

dipeptidase 1 (renal)

3,09

3,6E−05

 

FAM221B

family with sequence similarity 221 member B

3,09

6,6E−04

 

RFWD2

ring finger and WD repeat domain 2

3,12

9,1E−29

 

NRAP

nebulin related anchoring protein

3,16

5,8E−07

 

ST3GAL3

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

3,19

9,3E−07

 

SLC1A1

solute carrier family 1 member 1

3,27

3,3E−05

 

RPL37

ribosomal protein L37

3,33

2,4E−04

 

CALB1

calbindin 1

3,42

2,8E−04

 

HSD11B2

hydroxysteroid 11-beta dehydrogenase 2

3,53

2,0E−06

 

LOC105607801

uncharacterized LOC105607801

3,53

7,4E−06

 

TCF12

transcription factor 12

3,58

4,1E−04

 

LOC105613004

C-type lectin domain family 12 member B-like

3,59

1,1E−06

 

LOC105609641

uncharacterized LOC105609641

3,61

3,9E−05

 

TCFL5

transcription factor like 5

3,69

2,1E−09

 

FGD4

FYVE, RhoGEF and PH domain containing 4

3,82

1,0E−10

 

GABPB1

GA binding protein transcription factor beta subunit 1

3,84

1,6E−09

 

CASP7

caspase 7

3,86

4,3E−07

 

OTOP2

otopetrin 2

3,90

5,0E−04

 

LTA4H

leukotriene A4 hydrolase

3,95

1,0E−06

 

LOC101105609

BOLA class I histocompatibility antigen, alpha chain BL3-7

3,98

1,4E−06

 

LOC101114239

A-kinase anchor protein 2

4,00

1,5E−06

 

LOC101107891

zinc finger protein 160-like

4,10

2,9E−11

 

LOC101104114

serpin B4-like

4,12

3,2E−04

 

MYH7

myosin heavy chain 7

4,40

4,6E−04

 

SLC51A

solute carrier family 51 alpha subunit

4,46

7,6E−10

 

NAALADL2

N-acetylated alpha-linked acidic dipeptidase like 2

4,47

6,1E−05

 

NINJ2

ninjurin 2

4,51

3,0E−07

 

ABCA12

ATP binding cassette subfamily A member 12

4,62

6,9E−12

 

TOX4

TOX high mobility group box family member 4

4,65

3,7E−05

 

MAPK4

mitogen-activated protein kinase 4

4,70

3,0E−14

 

NMB

neuromedin B

4,77

1,1E−06

 

GPATCH2L

G-patch domain containing 2 like

4,85

4,5E−10

 

NAALADL1

N-acetylated alpha-linked acidic dipeptidase like 1

4,95

1,6E−05

 

TRNAE−UUC

transfer RNA glutamic acid (anticodon UUC)

4,98

1,4E−12

 

GPR15

G protein-coupled receptor 15

5,13

7,4E−16

 

NIPAL1

NIPA like domain containing 1

5,15

2,1E−05

 

LOC101105044

plasminogen activator inhibitor 2

5,34

8,3E−04

 

SLIT1

slit guidance ligand 1

5,40

9,9E−04

 

TTYH3

tweety family member 3

5,44

2,4E−34

 

LOC106991502

uncharacterized LOC106991502

5,45

6,4E−04

 

LOC105604901

uncharacterized LOC105604901

5,45

8,0E−04

 

WDR17

WD repeat domain 17

5,46

9,2E−04

 

NME5

NME/NM23 family member 5

5,47

8,1E−04

 

ROBO1

roundabout guidance receptor 1

5,50

7,7E−04

 

HEPACAM

hepatic and glial cell adhesion molecule

5,51

6,5E−05

 

ORAI2

ORAI calcium release-activated calcium modulator 2

5,54

8,3E−04

 

TFAP2A

transcription factor AP-2 alpha

5,55

3,0E−04

 

ABLIM2

actin binding LIM protein family member 2

5,57

5,6E−04

 

MAST3

microtubule associated serine/threonine kinase 3

5,57

9,6E−12

 

TRNAW-CCA

transfer RNA tryptophan (anticodon CCA)

5,58

1,0E−03

 

DRD2

dopamine receptor D2

5,69

3,4E−04

 

PIGL

phosphatidylinositol glycan anchor biosynthesis class L

5,70

6,8E−04

 

ADPRM

ADP-ribose/CDP-alcohol diphosphatase, manganese dependent

5,70

7,9E−04

 

BMP3

bone morphogenetic protein 3

5,74

1,7E−04

 

CDH19

cadherin 19

5,74

5,8E−11

 

TATDN2

TatD DNase domain containing 2

5,77

1,2E−04

 

SATB2

SATB homeobox 2

5,77

2,3E−11

 

AZIN2

antizyme inhibitor 2

5,79

2,9E−04

 

LOC105605834

cationic amino acid transporter 3-like

5,83

1,6E−04

 

LOC106991065

uncharacterized LOC106991065

5,87

5,6E−05

 

LOC101123021

ras-related protein Rab-43

5,89

1,0E−03

 

CD320

CD320 molecule

5,91

3,4E−08

 

METTL16

methyltransferase like 16

5,96

7,2E−04

 

LOC105608151

uncharacterized LOC105608151

5,96

7,3E−05

 

RNF4

ring finger protein 4

5,99

5,4E−04

 

TRNAW-CCA

transfer RNA tryptophan (anticodon CCA)

6,01

4,1E−05

 

VEGFB

vascular endothelial growth factor B

6,03

7,3E−06

 

LOC101103612

serpin B3-like

6,05

1,5E−06

 

SLC10A2

solute carrier family 10 member 2

6,05

8,2E−06

 

SH3RF2

SH3 domain containing ring finger 2

6,05

1,4E−07

 

FAM217A

family with sequence similarity 217 member A

6,07

7,2E−04

 

FAM117A

family with sequence similarity 117 member A

6,11

2,0E−06

 

PKD2L1

polycystin 2 like 1, transient receptor potential cation channel

6,14

5,9E−04

 

PAX4

paired box 4

6,17

1,1E−21

 

PCTP

phosphatidylcholine transfer protein

6,22

9,0E−05

 

ADGRE1

adhesion G protein-coupled receptor E1

6,23

1,2E−05

 

TRIM67

tripartite motif containing 67

6,25

9,0E−04

 

LOC101121116

sialic acid-binding Ig-like lectin 5

6,30

3,0E−06

 

DNAJC13

DnaJ heat shock protein family (Hsp40) member C13

6,31

4,3E−05

 

SLC6A3

solute carrier family 6 member 3

6,33

2,9E−05

 

APOH

apolipoprotein H

6,39

1,3E−05

 

LOC106991822

serine/threonine-protein kinase MARK2-like

6,42

8,8E−04

 

PIGX

phosphatidylinositol glycan anchor biosynthesis class X

6,43

3,5E−04

 

TINAG

tubulointerstitial nephritis antigen

6,50

3,9E−05

 

LOC101121302

serine/threonine-protein kinase MARK2

6,50

5,8E−05

 

H6PD

hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

6,53

4,5E−05

 

BIRC6

baculoviral IAP repeat containing 6

6,53

4,4E−05

 

LOC105601985

sialic acid-binding Ig-like lectin 14

6,58

1,9E−04

 

WFIKKN2

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

6,64

4,5E−06

 

LOC101107003

leukocyte immunoglobulin-like receptor subfamily A member 4

6,69

3,6E−06

 

LOC105602452

uncharacterized LOC105602452

6,79

2,3E−05

 

IKZF2

IKAROS family zinc finger 2

6,80

1,0E−04

 

DNAH2

dynein axonemal heavy chain 2

6,82

2,0E−05

 

RPS17

ribosomal protein S17

6,87

6,3E−05

 

ATP6V0A4

ATPase H + transporting V0 subunit a4

6,94

6,1E−05

 

SCN3A

sodium voltage-gated channel alpha subunit 3

7,03

1,2E−04

 

LOC101105208

apoptosis-associated speck-like protein containing a CARD

7,15

5,9E−07

 

KCNT1

potassium sodium-activated channel subfamily T member 1

7,18

1,8E−04

 

TRNAD-GUC

transfer RNA aspartic acid (anticodon GUC)

7,19

1,6E−07

 

SLC5A8

solute carrier family 5 member 8

7,20

6,2E−06

 

TESK1

testis-specific kinase 1

7,23

1,4E−05

 

IL1RL2

interleukin 1 receptor like 2

7,26

1,0E−07

 

LOC105608936

nucleosome assembly protein 1-like 1

7,32

2,0E−04

 

SFR1

SWI5 dependent homologous recombination repair protein 1

7,35

4,8E−05

 

SLCO4C1

solute carrier organic anion transporter family member 4C1

7,37

1,3E−42

 

MAP3K13

mitogen-activated protein kinase kinase kinase 13

7,37

5,6E−04

 

ACADVL

acyl-CoA dehydrogenase, very long chain

7,39

2,8E−06

 

LOC101103863

52 kDa repressor of the inhibitor of the protein kinase-like

7,40

1,1E−07

 

SHBG

sex hormone binding globulin

7,40

1,9E−07

 

LPAR3

lysophosphatidic acid receptor 3

7,46

4,2E−06

 

MESP2

mesoderm posterior bHLH transcription factor 2

7,47

2,7E−07

 

OAS2

2’-5’-oligoadenylate synthetase 2

7,47

7,7E−05

 

BTBD11

BTB domain containing 11

7,51

9,9E−07

 

SPCS1

signal peptidase complex subunit 1

7,56

5,8E−07

 

LOC101116133

killer cell lectin-like receptor 2

7,58

5,9E−06

 

LOC101106326

adhesion G protein-coupled receptor E3-like

7,58

4,2E−08

 

LOC105603045

uncharacterized LOC105603045

7,60

3,9E−07

 

C25H10orf99

chromosome 25 open reading frame, human C10orf99

7,60

8,1E−09

 

NR1H2

nuclear receptor subfamily 1 group H member 2

7,68

1,9E−06

 

CA7

carbonic anhydrase 7

7,73

6,9E−09

 

UBR5

ubiquitin protein ligase E3 component n-recognin 5

7,77

5,7E−12

 

LOC101120782

mast cell protease 2-like

7,79

7,5E−09

 

GPR4

G protein-coupled receptor 4

7,86

6,3E−04

 

LOC101107261

mast cell protease 2-like

7,89

9,5E−06

 

LOC101104046

thiamine transporter 2-like

7,90

6,8E−04

 

FUT11

fucosyltransferase 11

7,97

8,8E−09

 

KMT2D

lysine methyltransferase 2D

8,06

5,5E−06

 

CTH

cystathionine gamma-lyase

8,23

9,8E−09

 

MYCBPAP

MYCBP associated protein

8,26

5,8E−08

 

ABCB8

ATP binding cassette subfamily B member 8

8,37

5,6E−08

 

DDX31

DEAD-box helicase 31

8,55

5,2E−05

 

MMP12

matrix metallopeptidase 12

8,56

7,2E−10

 

LOC101114535

C–C motif chemokine 3

8,69

2,2E−11

 

POLR3A

RNA polymerase III subunit A

8,74

2,6E−09

 

CA12

carbonic anhydrase 12

8,81

1,2E−24

 

PSTPIP1

proline-serine-threonine phosphatase interacting protein 1

9,24

7,2E−04

 

C11H17orf62

chromosome 11 open reading frame, human C17orf62

9,36

1,8E−19

 

RIPPLY1

ripply transcriptional repressor 1

9,38

9,2E−09

 

GRAMD1B

GRAM domain containing 1B

9,46

1,0E−06

 

LOC101108654

double-headed protease inhibitor, submandibular gland-like

9,47

3,4E−10

 

GAREM1

GRB2 associated regulator of MAPK1 subtype 1

9,49

1,2E−04

 

CSRNP2

cysteine and serine rich nuclear protein 2

9,91

4,0E−09

 

TMIGD1

transmembrane and immunoglobulin domain containing 1

9,97

5,9E−10

 

ARHGEF1

Rho guanine nucleotide exchange factor 11

9,99

2,9E−04

 

DHCR24

24-dehydrocholesterol reductase

10,04

1,5E−11

 

LOC101105348

choline transporter-like protein 2

10,05

3,3E−15

 

UGT1A4

UDP glucuronosyltransferase 1 family, polypeptide A4

10,07

4,6E−07

 

TMEM92

transmembrane protein 92

10,12

1,3E−11

 

EDEM3

ER degradation enhancing alpha-mannosidase like protein 3

10,14

2,1E−12

 

PLPP5

phospholipid phosphatase 5

10,28

4,1E−16

 

LOC105612984

uncharacterized LOC105612984

10,66

1,1E−04

 

HM13

histocompatibility minor 13

10,88

8,7E−04

 

TRNAC-GCA

transfer RNA cysteine (anticodon GCA)

11,03

1,0E−03

 

CCDC58

coiled-coil domain containing 58

11,04

8,3E−04

 

AURKB

aurora kinase B

11,10

4,5E−17

 

SAC3D1

SAC3 domain containing 1

11,12

1,0E−03

 

CA4

carbonic anhydrase 4

11,16

7,5E−19

 

SMLR1

small leucine rich protein 1

11,27

6,6E−04

 

AQR

aquarius intron-binding spliceosomal factor

11,91

4,5E−04

 

GPR1

G protein-coupled receptor 1

11,98

3,7E−04

 

SWI5

SWI5 homologous recombination repair protein

12,07

4,5E−04

 

LOC105605908

butyrophilin subfamily 1 member A1-like

12,40

2,7E−04

 

FABP6

fatty acid binding protein 6

12,53

5,6E−19

 

GIT2

GIT ArfGAP 2

16,77

1,5E−10

 

GAL3ST3

galactose-3-O-sulfotransferase 3(GAL3ST3)

27,24

1,3E−14

  1. Among these, 342 genes were upregulated, while 242 were downregulated. (excluding unpredicted genes), FDR < 0.05.