Table 7 A total of 332 differentially expressed genes (DEGs) were identified in the duodenum between resistant and susceptible animals (FDR < 0.05 and log2fold change > 2). Of these, 206 genes were upregulated, while 126 genes were downregulated. (excluding unpredicted genes), FDR < 0.05.

Downregulated

SWSAP1

SWIM-type zinc finger 7 associated protein 1

− 30,00

1,8E−15

SIRT7

sirtuin 7

− 29,00

3,2E−15

GIT2

GIT ArfGAP 2

− 13,93

3,4E−24

BATF2

basic leucine zipper ATF-like transcription factor 2

− 13,45

1,1E−04

LOC105602872

uncharacterized LOC105602872

− 12,23

2,9E−04

LOC101114922

selection and upkeep of intraepithelial T-cells protein 8-like

− 12,21

3,7E−04

LOC101119090

40S ribosomal protein S27-like

− 12,01

3,6E−04

LLGL2

LLGL2, scribble cell polarity complex component

− 11,48

5,2E−14

COPB1

coatomer protein complex subunit beta 1

− 11,42

6,5E−17

AMFR

autocrine motility factor receptor

− 11,00

9,8E−05

MPND

MPN domain containing

− 10,47

1,0E−11

GPN2

GPN-loop GTPase 2

− 10,42

2,0E−07

PRAF2

PRA1 domain family member 2

− 10,30

2,2E−12

SSH3

slingshot protein phosphatase 3

− 10,14

1,9E−12

B4GALNT1

beta-1,4-N-acetyl-galactosaminyltransferase 1

− 10,03

7,4E−08

PTPN4

protein tyrosine phosphatase, non-receptor type 4

− 10,02

2,1E−08

MIF4GD

MIF4G domain containing

− 9,84

3,0E−04

ECH1

enoyl-CoA hydratase 1

− 9,73

1,9E−07

SHISA4

shisa family member 4

− 9,04

1,5E−04

LOC101104808

aldehyde oxidase 4-like

− 8,96

9,1E−06

LOC101113251

arachidonate 12-lipoxygenase, epidermal-type-like

− 8,14

2,2E−04

TRNAC-ACA

transfer RNA cysteine (anticodon ACA)

− 8,12

1,0E−21

AKAP17A

A-kinase anchoring protein 17A

− 8,06

4,3E−09

LOC101111190

hepatitis A virus cellular receptor 1-like

− 7,81

3,4E−05

ALDH8A1

aldehyde dehydrogenase 8 family member A1

− 7,80

1,4E−06

NUDT3

nudix hydrolase 3

− 7,67

1,2E−04

FLRT3

fibronectin leucine rich transmembrane protein 3

− 7,43

3,8E−06

ARHGEF40

Rho guanine nucleotide exchange factor 40

− 7,02

2,7E−04

SLC35D3

solute carrier family 35 member D3

− 6,97

1,3E−05

LOC101119456

protein SET

− 6,92

7,6E−05

LOC105611558

uncharacterized LOC105611558

− 6,73

3,2E−04

SFSWAP

splicing factor SWAP homolog

− 6,70

2,8E−05

TIMM50

translocase of inner mitochondrial membrane 50

− 6,63

2,7E−04

TMEM55B

transmembrane protein 55B(TMEM55B)

− 6,61

8,4E−05

PDIA2

protein disulfide isomerase family A member 2

− 6,60

1,7E−07

MYL4

myosin light chain 4

− 6,48

3,8E−05

FAM184A

family with sequence similarity 184 member A

− 6,47

1,6E−05

NAIF1

nuclear apoptosis inducing factor 1(NAIF1)

− 6,46

1,1E−04

LOC106991822

serine/threonine-protein kinase MARK2-like

− 6,32

1,8E−04

GOLGA4

golgin A4

− 6,29

8,3E−09

PDE6C

phosphodiesterase 6C

− 6,07

3,2E−04

HSF1

heat shock transcription factor 1

− 5,95

8,7E−05

CEP76

centrosomal protein 76

− 5,88

3,4E−04

VPS28

VPS28, ESCRT-I subunit

− 5,81

1,3E−08

PTPN3

protein tyrosine phosphatase, non-receptor type 3

− 5,66

7,6E−06

RPS27

ribosomal protein S27

− 5,51

9,9E−05

BGLAP

bone gamma-carboxyglutamate protein

− 5,35

1,3E−16

LDHB

lactate dehydrogenase B

− 5,00

2,7E−04

LOC101115959

TRPM8 channel-associated factor 2

− 4,90

4,0E−04

LOC105607217

uncharacterized LOC105607217

− 4,55

3,0E−09

CELF1

CUGBP, Elav-like family member 1

− 4,52

2,9E−07

LOC105606766

COPII coat assembly protein sec16-like

− 4,31

3,5E−04

PDXDC1

pyridoxal dependent decarboxylase domain containing 1

− 4,19

3,9E−04

TRNAI-UAU

transfer RNA isoleucine (anticodon UAU)

− 4,10

7,1E−07

NR4A2

nuclear receptor subfamily 4 group A member 2

− 4,02

3,1E−04

SULF2

sulfatase 2

− 4,01

1,3E−04

IGSF9

immunoglobulin superfamily member 9

− 3,66

7,8E−06

ACVR2B

activin A receptor type 2B

− 3,48

9,2E−06

NDUFS7

NADH: ubiquinone oxidoreductase core subunit S7

− 3,45

8,7E−07

CLPX

caseinolytic mitochondrial matrix peptidase chaperone subunit

− 3,37

1,2E−05

LTBR

lymphotoxin beta receptor

− 3,36

3,5E−07

KLHDC3

kelch domain containing 3

− 3,33

9,4E−08

EDEM1

degradation enhancing alpha-mannosidase like protein 1

− 3,32

5,0E−04

NR2F6

nuclear receptor subfamily 2 group F member 6

− 3,21

1,8E−14

MAST4

microtubule associated serine/threonine kinase family member 4

− 2,99

6,3E−09

MCAM

melanoma cell adhesion molecule

− 2,90

4,2E−05

MAP2K6

mitogen-activated protein kinase kinase 6

− 2,82

1,9E−06

DGKA

diacylglycerol kinase alpha

− 2,45

1,3E−04

USP54

ubiquitin specific peptidase 54

− 2,44

2,6E−04

LOC101105356

KDEL motif-containing protein 2

− 2,41

5,9E−06

TSPYL2

TSPY like 2

− 2,41

1,2E−07

GTPBP2

GTP binding protein 2

− 2,40

1,7E−04

ARF3

ADP ribosylation factor 3

− 2,37

1,7E−04

C13H20orf96

chromosome 13 open reading frame, human C20orf96

− 2,33

2,8E−04

BPTF

bromodomain PHD finger transcription factor

− 2,23

5,0E−04

DNAH11

dynein axonemal heavy chain 11

− 2,14

6,2E−06

MAN2B1

mannosidase alpha class 2B member 1

− 2,12

1,8E−05

Upregulated

SLC2A2

solute carrier family 2 member 2

2,05

5,3E−05

GULP1

GULP, engulfment adaptor PTB domain containing 1

2,25

3,2E−04

IVNS1ABP

influenza virus NS1A binding protein

2,27

4,9E−04

CCNL1

cyclin L1

2,29

6,3E−08

BLZF1

basic leucine zipper nuclear factor 1

2,30

3,4E−04

SPINK4

serine peptidase inhibitor, Kazal type 4

2,40

2,0E−04

LRRTM1

leucine rich repeat transmembrane neuronal 1

2,52

1,5E−04

LOC105616742

endogenous retrovirus group K member 5 Gag polyprotein

2,52

1,1E−05

LOC101120877

histone H3

2,55

8,6E−06

MFAP2

microfibrillar associated protein 2

2,57

9,2E−07

CNDP2

CNDP dipeptidase 2 (metallopeptidase M20 family)

2,70

1,5E−04

BRICD5

BRICHOS domain containing 5

2,70

5,2E−04

CFHR5

complement factor H related 5

2,76

4,2E−04

ARPC5

actin related protein 2/3 complex subunit 5

2,92

2,0E−05

REG4

regenerating family member 4

2,99

1,1E−04

LOC105606132

mucin-2-like

3,01

2,1E−06

LPP

LIM domain containing preferred translocation partner in lipoma

3,17

1,4E−04

ZNF274

zinc finger protein 274

3,31

5,4E−04

ZNF513

zinc finger protein 513

3,37

1,9E−04

ZNF331

zinc finger protein 331

3,41

1,4E−06

ZSCAN23

zinc finger and SCAN domain containing 23

3,63

4,5E−04

LOC106992032

HLA class II histocompatibility antigen, DQ beta 1 chain pseudogene

3,66

5,1E−04

LOC106991426

uncharacterized LOC106991426

3,73

2,6E−04

TRIM14

tripartite motif containing 14

3,86

1,2E−04

GALNT16

polypeptide N-acetylgalactosaminyltransferase 16

4,01

2,5E−05

TMEM30B

transmembrane protein 30B

4,02

1,1E−10

ANXA5

annexin A5

4,22

2,4E−04

TNFSF9

tumor necrosis factor superfamily member 9

4,39

3,7E−04

LOC101113715

mucosal pentraxin

4,40

5,7E−05

LUC7L3

LUC7 like 3 pre-mRNA splicing factor

4,50

4,9E−04

WDR55

WD repeat domain 55

4,53

1,5E−04

LOC101107420

phospholipase A2, membrane associated

4,55

6,3E−07

LOC101109783

apolipoprotein L3-like

4,78

4,4E−04

SENP7

SUMO1/sentrin specific peptidase 7

5,07

2,4E−04

RNF167

ring finger protein 167

5,08

4,6E−05

LOC101107675

phospholipase A2, membrane associated-like

5,09

2,6E−06

TCHP

trichoplein keratin filament binding

5,10

2,2E−05

ABCC5

ATP binding cassette subfamily C member 5

5,22

5,3E−04

CLCC1

chloride channel CLIC like 1

5,24

1,6E−06

LOC101119214

olfactory receptor 10H2-like

5,25

2,4E−05

GDA

guanine deaminase

5,34

6,2E−12

LOC101116867

interferon alpha-inducible protein 27-like protein 2

5,43

3,3E−04

LGALS8

galectin 8

5,57

4,8E−05

ISLR

immunoglobulin superfamily containing leucine rich repeat

5,59

1,5E−04

TMBIM1

transmembrane BAX inhibitor motif containing 1

5,68

1,3E−06

LOC105602784

uncharacterized LOC105602784

5,73

2,0E−04

SFTA2

surfactant associated 2

5,78

4,3E−04

LOC105612255

uncharacterized LOC105612255

5,80

2,9E−04

LOC105613828

uncharacterized LOC105613828

5,82

2,0E−04

RCAN3

RCAN family member 3

5,84

3,4E−04

ERO1A

endoplasmic reticulum oxidoreductase 1 alpha

5,87

3,1E−04

LOC105616902

uncharacterized LOC105616902

5,98

7,1E−05

LOC105609244

uncharacterized LOC105609244

6,00

2,0E−04

CLCA2

chloride channel accessory 2

6,04

4,5E−04

LOC101105119

uncharacterized LOC101105119

6,05

6,8E−05

KLHL7

kelch like family member 7

6,12

4,3E−04

LOC105604756

uncharacterized LOC105604756

6,27

7,9E−05

PKP2

plakophilin 2

6,35

2,6E−04

PHEX

phosphate regulating endopeptidase homolog, X-linked

6,44

8,4E−05

NFE2L1

nuclear factor, erythroid 2 like 1

6,45

3,5E−04

LOC105601913

lck-interacting transmembrane adapter 1-like

6,51

4,5E−05

FCER1A

Fc fragment of IgE receptor Ia

6,59

4,0E−04

DMTF1

cyclin D binding myb like transcription factor 1

6,63

1,5E−08

TRIP13

thyroid hormone receptor interactor 13

6,85

5,1E−04

SPAG17

sperm associated antigen 17

6,89

2,4E−05

LOC106990184

uncharacterized LOC106990184

6,92

1,1E−06

SPAG4

sperm associated antigen 4

7,07

2,9E−05

BRD3

bromodomain containing 3

7,08

2,5E−13

C20H6orf136

chromosome 20 open reading frame, human C6orf136

7,21

1,4E−05

PSME1

proteasome activator subunit 1

7,30

3,3E−05

ZSCAN29

zinc finger and SCAN domain containing 29

7,30

1,9E−04

CPO

carboxypeptidase O

7,35

6,2E−05

LOC101113832

agrin-like

7,42

3,7E−07

ERO1B

endoplasmic reticulum oxidoreductase 1 beta

7,47

1,5E−04

PCGF1

polycomb group ring finger 1

7,48

2,5E−04

PXMP4

peroxisomal membrane protein 4

7,54

1,2E−10

WDPCP

WD repeat containing planar cell polarity effector

7,55

1,4E−07

LOC105605834

cationic amino acid transporter 3-like

7,55

1,3E−04

CCDC85C

coiled-coil domain containing 85C

7,56

3,8E−05

TMEM244

transmembrane protein 244

7,62

1,0E−05

LOC101103215

SCAN domain-containing protein 1-like

7,68

1,3E−09

MYO6

myosin VI

7,70

1,5E−05

UBR5

ubiquitin protein ligase E3 component n-recognin 5

7,79

1,8E−04

KCNE4

potassium voltage-gated channel subfamily E regulatory subunit 4

8,04

1,5E−06

TSTD2

thiosulfate sulfurtransferase like domain containing 2

8,10

3,3E−09

GLTPD2

glycolipid transfer protein domain containing 2

8,13

8,0E−05

MTCL1

microtubule crosslinking factor 1

8,18

1,7E−06

NSUN6

NOP2/Sun RNA methyltransferase family member 6

8,48

1,9E−08

LOC101102714

lysozyme C, milk isozyme

8,59

2,7E−05

POLK

DNA polymerase kappa

8,87

1,2E−10

MRPL36

mitochondrial ribosomal protein L36

8,93

6,7E−09

VWA1

von Willebrand factor A domain containing 1

9,00

1,4E−11

POF1B

premature ovarian failure, 1B

9,01

1,3E−09

MEMO1

mediator of cell motility 1

9,03

6,6E−05

AASS

aminoadipate-semialdehyde synthase

9,05

1,1E−04

CPEB3

cytoplasmic polyadenylation element binding protein 3

9,07

3,6E−06

CHML

CHM like, Rab escort protein 2

9,16

1,6E−09

HERC5

HECT and RLD domain containing E3 ubiquitin protein ligase 5

9,29

1,2E−09

ZFP57

ZFP57 zinc finger protein

9,40

4,4E−10

TBC1D17

TBC1 domain family member 17

9,44

1,1E−07

GULP1

GULP, engulfment adaptor PTB domain containing 1

9,46

2,0E−12

SCFD1

sec1 family domain containing 1

9,59

6,5E−09

MPRIP

myosin phosphatase Rho interacting protein

9,60

4,9E−04

ZNF592

zinc finger protein 592

9,75

6,1E−08

LOC105602450

uncharacterized LOC105602450

9,79

4,6E−11

CD226

CD226 molecule

9,90

2,8E−11

SCARB1

scavenger receptor class B member 1

9,91

1,9E−13

LHFP

lipoma HMGIC fusion partner

10,08

6,3E−13

SLC25A30

solute carrier family 25 member 30

10,10

6,7E−13

GON4L

gon-4 like

10,42

1,3E−06

ISX

intestine specific homeobox

10,50

2,8E−09

DNMBP

dynamin binding protein (DNMBP)

10,71

7,9E−06

IRAK4

interleukin 1 receptor associated kinase 4

11,19

7,7E−06

CEP152

centrosomal protein 152

11,64

1,3E−18

EGFLAM

EGF like, fibronectin type III and laminin G domains

11,87

4,9E−04

TTC32

tetratricopeptide repeat domain 32

11,87

4,7E−04

TNFRSF1B

TNF receptor superfamily member 1B

11,92

1,4E−17

PCDH12

protocadherin 12

11,93

5,3E−14

GAL3ST3

galactose-3-O-sulfotransferase 3

12,07

4,3E−04

DSG1

desmoglein 1

12,59

2,7E−04

CDH17

cadherin 17

12,62

2,7E−04

HCN2

hyperpolarization activated cyclic nucleotide gated potassium channel 2

13,02

2,0E−04

GALNT1

polypeptide N-acetylgalactosaminyltransferase 16

13,13

1,9E−23