Table 8 The analysis of fold enrichment in KEGG pathways was conducted using all differentially expressed genes across various study segments, as well as in both resistant and susceptible animals.

From: Differential gene expression analysis of Dohne Merino sheep naturally infected with Haemonchus contortus

	KEEG pathways	Genes symbols	P-value	Fold enrichment
Resistance and susceptible animals	Rap1 signaling pathway	FARP2, PGF	2.0E−1	8.3
	PI3K-Akt signaling pathway	CDKN1A, PGF	3.1E− 1	4.9
	Pathways in cancer	CDKN1A, PGF	5.9E− 2	6.5
Abomasum	Central carbon metabolism in cancer	RET, PDHA1, SLC2A1	0.03	10.30
	Non-small cell lung cancer	EML4, RET, POLK	0.03	10.02
	Pathways in cancer	EML4, RET, GNG4, SLC2A1, POLK, EPOR	0.06	2.69
	Glucagon signaling pathway	CPT1A, PDHA1, SLC2A1	0.07	6.97
	Thyroid cancer	RET, POLK	0.15	11.89
	PI3K-Akt signaling pathway	NR4A1, LOC101122444, GNG4, EPOR	0.19	2.59
	Ras signaling pathway	SYNGAP1, GNG4, RASAL2	0.24	3.14
	Adipocytokine signaling pathway	CPT1A, SLC2A1	0.25	6.77
	Adherens junction	YES1, PARD3	0.25	6.68
	Insulin resistance	CPT1A, SLC2A1	0.36	4.43
	HIF-1 signaling pathway	PDHA1, SLC2A1	0.37	4.32
	Nucleocytoplasmic transport	RBM8A, XPOT	0.39	3.97
	Cell cycle	E2F4, BUB1	0.40	3.84
	Spliceosome	SF3A2, RBM8A	0.47	3.09
	Cellular senescence	MYBL2, E2F4	0.48	2.97
Duodenum	Fat digestion and absorption	SCARB1, LOC101107675, LOC101107420	0.06	7.31
	Arachidonic acid metabolism	LOC101107675, LOC101107420, LOC101113251	0.13	4.70
	Protein processing in endoplasmic reticulum	ERO1A, ERO1B, AMFR, EDEM1	0.15	2.91
	Glycerophospholipid metabolism	DGKA, LOC101107675, LOC101107420	0.18	3.84
	Pancreatic secretion	CLCA2, LOC101107675, LOC101107420	0.18	3.80
	alpha-Linolenic acid metabolism	LOC101107675, LOC101107420	0.19	9.05
	Mucin type O-Glycan biosynthesis	GALNT16, GALNT1	0.23	7.68
	Linoleic acid metabolism	LOC101107675, LOC101107420	0.24	7.24
	Cytokine-cytokine receptor interaction	TNFSF9, LTBR, TNFRSF1B, ACVR2B	0.26	2.23
	Metabolic pathways	GALNT16, GDA, DGKA, GALNT1, LOC101107675, LOC101107420, CNDP2, LDHB, NDUFS7, B4GALNT1, LOC101104808, AASS, LOC101113251	0.28	1.29
	Endocytosis	ARF3, GIT2, ARPC5, VPS28	0.32	1.99
	Ether lipid metabolism	LOC101107675, LOC101107420	0.32	5.17
	Amyotrophic lateral sclerosis (ALS)	TNFRSF1B, MAP2K6	0.33	4.87
	Fc epsilon RI signaling pathway	FCER1A, MAP2K6	0.40	3.89
	Influenza A	IVNS1ABP, IRAK4, MAP2K6	0.43	2.04
	Aldosterone synthesis and secretion	NR4A2, SCARB1	0.45	3.29
	Peroxisome	ECH1, PXMP4	0.48	3.02
Ileum	Renin-angiotensin system	LOC101107261, LOC101120782, MME	0.02	12.30
	ABC transporters	LOC105606000, TAP2, LOC101104054	0.09	5.75
	Inositol phosphate metabolism	INPP4B, MTMR1, SYNJ2	0.13	4.82
	Complement and coagulation cascades	LOC101123419, CFB, LOC101122294	0.14	4.52
	Antigen processing and presentation	TAP2, CTSV, OLA-I	0.16	4.10
	Phosphatidylinositol signaling system	INPP4B, MTMR1, SYNJ2	0.20	3.53
	Viral carcinogenesis	DLG1, EP300, OLA-I, CCR3	0.28	2.14
	Ubiquitin mediated proteolysis	CDC27, UBE4A, BIRC6	0.33	2.49
	Notch signaling pathway	EP300, DTX2	0.35	4.57
	HTLV-I infection	DLG1, CDC27, EP300, OLA-I	0.41	1.70
	Protein processing in endoplasmic reticulum	EDEM3, BAG1, DERL2	0.42	2.06
	Phagosome	TAP2, CTSV, OLA-I	0.44	2.00
	Staphylococcus aureus infection	LOC101123419, CFB	0.45	3.35
Jejunum	PPAR signaling pathway	FABP1, FABP6, APOC3, PPARG, PLIN1, SLC27A2, ACSBG2	0.001	5.29
	Chemical carcinogenesis	GSTA1-1, LOC101120103, GSTA1, LOC101119842, UGT1A4, CYP3A24, LOC101107486	0.002	4.88
	Steroid hormone biosynthesis	HSD11B2, LOC101109633, UGT1A4, CYP3A24, LOC101107541, LOC101107486	0.010	4.47
	Phagosome	COLEC11, NCF1, LAMP1, NCF2, SFTPD, ATP6V0A4, TUBB4A, LOC101105609, LOC101108297	0.019	2.68
	Bile secretion	SLC9A3, SLC10A2, LOC101120103, LOC101119842, SLC51A, SLC51B	0.02	3.74
	Metabolism of xenobiotics by cytochrome P450	GSTA1-1, LOC101120103, GSTA1, LOC101119842, UGT1A4	0.04	3.95
	Nitrogen metabolism	CA12, CA4, CA7	0.04	9.34
	Chemokine signaling pathway	SHC4, LOC101114535, CXCL11, CXCL9, NCF1, GNG4, CXCR2, LOC101104661	0.04	2.46
	Arachidonic acid metabolism	LOC101109633, LOC101107541, LTA4H, LOC101107486, LOC101118441	0.07	3.27
	Metabolic pathways	ACADVL, H6PD, TREH, LOC101107541, LOC101107486, PIGX, SMPD3, UGT1A4, ATP6V0A4, HMGCS2, LTA4H, EXTL3, ACADS, EARS2, ST3GAL3, MCCC2, CERS5, AGXT2, LOC101109633, MBOAT1, AZIN2, CYP3A24, DHCR24, BPGM, NME5, POLR3A, BDH1, CTH, PIGL, LCT, ACSBG2, LOC101118441	0.08	1.32

This analysis aimed to elucidate the biological pathways involved in the response of resistant and susceptible animals to H. contortus.

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Table 8 The analysis of fold enrichment in KEGG pathways was conducted using all differentially expressed genes across various study segments, as well as in both resistant and susceptible animals.

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