Fig. 3
From: Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players
DNA methylation alterations and biological associations in epigenetically-accelerated elite soccer players. (A) Bar plots showing the number of DMCs (FDR < 0.05, methylation difference > 5%) between positive-EAA and negative-EAA athletes. (B) Upset plot indicating the numbers and intersections of significant (FDR < 0.05) Gene Ontology pathways found enriched for the DMCs. (C) Bubble plot displaying the Gene Ontology pathways found enriched in comparisons involving 3 or more clocks. (D) Upset plot showing the numbers and intersections of significant (FDR < 0.05) Canonical Pathways gene sets found enriched for the DMCs. (E) Bubble plot indicating the Canonical Pathways gene sets found enriched in comparisons involving 2 or more clocks. (F) Genome profile plots showing the methylation difference levels between positive-EAA and negative-EAA athletes defined by the PhenoAge (left) and Zhang2019 EN (right) clocks for all of the CpG sites associated with the COL23A1 gene. Statistically significant changes (FDR < 0.05, methylation difference > 5%) are marked in red.
