Table 1 Laboratory parameters of mice in the untreated and treated groups.

From: Magnetic hyperthermia using iron oxide nanoparticles via LDDS suppressed lymph node and lung metastasis in a mouse model

 

Ref.

Untreated

Resovist

Hyperthermia

Combination

 

P-value

 

P-value

 

P-value

 

P-value

ALT (U/L)

110 (14.8)

121.8 (13.2)

 

160.4 (15.3)

0.001

116.4 (22.5)

 

103.6 (7.3)

 

AST (U/L)

57 (4.5)

57.3 (4.3)

0.028

70.4 (5.5)

 

59.6 (4.3)

 

55.3 (4.8)

0.002

WBC (103/uL)

11 (14.8)

8.9 (1.5)

 

17.9 (2.3)

0.010

18.2 (3.4)

0.0178

10.2 (1.6)

 

RBC (106/uL)

6.9 (1.1)

10.5 (0.4)

 

8.6 (1.0)

 

9.8 (1.0)

 

9.5 (0.9)

 

Hgb (g/dL)

17.0 (0.4)

17.8 (0.5)

 

19.5 (1.6)

 

20.3 (1.1)

 

18.0 (1.5)

 

HCT (%)

47.5 (1.3)

48.5 (1.9)

 

43.0 (4.3)

 

48.1 (4.4)

 

45.3 (4.4)

 

MCV (µm3)

56.0 (1.3)

46.3 (0.4)

0.001

50.3 (2.0)

 

49.6 (0.9))

 

47.7 (0.6)

0.008

MCH (pg)

20.0 (0.3)

17.0 (0.2)

 

23.4 (2.3)

 

21.5 (1.8)

 

19.1 (0.9)

 

MCHC (g/dL)

35.8 (1.2)

36.7 (0.6)

 

46.1 (3.3)

0.015

43.1 (3.0)

 

40.0 (1.5)

 

RDW (%)

14.6 (0.3)

12.5 (0.2)

 

15.7 (1.2)

 

15.4 (1.1)

 

14.0 (0.7)

 

PLT (103/uL)

725.8 (248.1)

526.5 (76.7)

 

1374 (368.4)

 

1425 (370.4)

 

1054 (244.9)

 

MPV (µm3)

6.7 (0.2)

7.4 (0.1)

0.0352

6.9 (0.2)

 

6.8 (0.1)

 

7.0 (0.1)

 

PDW (%)

12.0 (0.8)

17.1 (1.2)

0.0167

13.4 (1.2)

 

12.3 (0.5)

 

13.2 (1.0)

 

PCT (%)

0.3 (0.1)

0.4 (0.1)

 

0.4 (0.0)

 

0.4 (0.0)

 

0.4 (0.0)

 
  1. Data shown as the mean ± SEM. Kruskal-Wallis (ns, P > 0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).
  2. Abbreviations: ALT, alanine transaminase; AST, aspartate aminotransferase; WBC, white blood cell; RBC, red blood cell; Hgb, hemoglobin; HCT, Hematocrit; MCV, mean cell volume; MCH, mean corpuscular hemoglobin; MCHC, mean cell hemoglobin concentration; RDW, red blood cell distribution width; PLT, platelet count; MPV, mean platelet volume; PDW, platelet volume; PCT, procalcitonin.
Back to article page