Table 6 Linear regression analysis for the associations between high-density cholesterol (HDL) and the risk of biological age acceleration, weighted.

From: Association of uric acid to high-density cholesterol ratio (UHR) with biological age acceleration: evidence from NHANES 2009–2018

 

Model 1

Model 2

Model 3

β (95%CI)

p-value

β (95%CI)

p-value

β (95%CI)

p-value

Phenotypic age acceleration

Continuous

-1.24 (-1.30, -1.18)

< 0.001

-1.05 (-1.11, -0.99)

< 0.001

-0.71 (-0.77, -0.66)

< 0.001

Categories

Tertiles 1

Reference

Reference

Reference

Tertiles 2

-1.52 (-1.67, -1.38)

< 0.001

-1.19 (-1.33, -1.05)

< 0.001

-0.70 (-0.83, -0.56)

< 0.001

Tertiles 3

-2.93 (-3.07, -2.78)

< 0.001

-2.38 (-2.53, -2.24)

< 0.001

-1.54 (-1.68, -1.40)

< 0.001

p for trend

< 0.001

< 0.001

< 0.001

KDM age acceleration

Continuous

-0.78 (-0.89, -0.68)

< 0.001

-0.57 (-0.68, -0.47)

< 0.001

-0.15 (-0.26, -0.04)

< 0.001

Categories

Tertiles 1

Reference

Reference

Reference

Tertiles 2

-1.35 (-1.60, -1.10)

< 0.001

-1.14 (-1.39, -0.88)

< 0.001

-0.58 (-0.82, -0.33)

< 0.001

Tertiles 3

-1.90 (-2.15, -1.65)

< 0.001

-1.44 (-1.70, -1.18)

< 0.001

-0.45 (-0.72, -0.20)

< 0.001

p for trend

< 0.001

< 0.001

< 0.001

  1. Model 1 was crude model. Model 2 was adjusted for age, sex, and race. Model 3 was further adjusted for education level, alcohol consumption, smoking status, cardiovascular disease, hypertension, diabetes, cancer, and physical activity. Continuous, standardized high-density cholesterol (HDL). p for trend was tested by incorporating the variables of the median of each quartile into the regression model.