Fig. 9
Luteolin inhibits the tumor growth of PANC-1 xenografts in nude mice in vivo. (A) The management of PANC-1 xenografts nude mice. (B) Images of tumors at the end of experiment. The mice were administered normal saline (vehicle control), luteolin (180 mg/kg/day, treatment control). Luteolin and normal saline were orally administered by gavage once a day for 14 days. (C) The weight of tumor between luteolin and control group. (D) The tumor volume between the luteolin and control group. (E) The bodyweight of mice between the luteolin and control group. (F) Histopathological examination of organs from PANC-1 xenograft mice after the administration of luteolin or saline. Formalin-fixed organs (heart, liver and kidney) were stained by hematoxylin and eosin. Scale bars represent 100 μm. (G) Luteolin significantly decreased the mitotic event index of the tumor and the expression level of CCNB1. A total of 5 mice were used in each group. The data are expressed as the mean ± SD. ***P<0.001.
