Fig. 4

Body and spleen weight analysis of the mice on Day 30 after 0 (0.9% NaCl), 18.5, 37.0 and 74.0 MBq/kg ¹⁶⁶Ho-EDTMP and ¹⁶⁶Ho-DOTMP-injected doses, n = 4–5, mean ± SD. (a) Body weights of the mice in the 0.9% NaCl and ¹⁶⁶Ho-EDTMP-injected groups. There were no significant differences in weight (P = 0.7255, two-way ANOVA with Tukey’s multiple comparisons test). (b) Body weights of the mice in the 0.9% NaCl and ¹⁶⁶Ho-DOTMP-injected groups. There were significant differences in weight decrease (P < 0.0001, two-way ANOVA). (c) Spleen weights of the mice in the 0.9% NaCl, ¹⁶⁶Ho-EDTMP and ¹⁶⁶Ho-DOTMP-injected groups. There were no significant differences in spleen weight (P = 0.4010, two-way ANOVA).