Fig. 6 | Scientific Reports

Fig. 6

From: Acute radiotoxicity studies and safety assessment of 166Ho-EDTMP and 166Ho-DOTMP for the palliative treatment of bone metastases

Fig. 6

Microscopy images of the bone marrow from the femur and sternum, which represent bone tissues from the male and female groups (n = 5), injected with different doses of 166Ho-EDTMP and 166Ho-DOTMP. Observations were made on Day 30 postinjection, with the tissues decalcified, H&E stained, and photomicrographed using an Olympus DP74 microscope at 400× magnification. White arrow: Megakaryocyte, a large hematopoietic cell characterized by a multilobed nucleus. Gray arrow: Lymphoblast cell, identified by its 1–2 nucleoli, scant cytoplasm, and round or slightly irregular nucleus. Black arrow: Myeloblast cells, large hematopoietic precursor cells with scant cytoplasm, round or slightly irregular nuclei, fine chromatin, and 3–5 nucleoli.

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