Table 3 Distribution of the plasma factors in participants.

From: Biochemical, immune, and endocrine biomarkers associated with exacerbated muscular response: insights from a field-based operational cohort study

Parameter

Unit

Moderate muscular response

Exacerbated muscular response

P-value

N – no.

 

26

28

 

CKMB

U/L

15.5 (11.7–21)

65.5 (36.2–94.7)

< 0.001

LDH

U/L

591.5 (537.3–689.3.3.3)

1206 (927–1560)

< 0.001

AST

U/L

51.5 (31.5–60)

128.5 (91.5–239)

< 0.001

ALT

U/L

46 (30.5–55.7)

69 (48.7–99)

< 0.001

GGT

U/L

20 (15.7–32.7)

23 (15.5–30)

0.63

Serum Albumin

g/dL

4.5 (4.2–4.8)

4.5 (4.1–4.8)

0.78

Serum Protein

g/dL

7.4 (7.1–7.8)

7.5 (7.1–7.9)

0.67

Urea

mg/dL

40.5 (35.7–47.2)

47.5 (37.5–55)

0.02

Creatinine

mg/dL

1.0 (0.9–1.1)

1.0 (0.9–1.1)

0.26

GFR

mL/min/1.73 m2

104.8 (90.1–118.6.1.6)

110.4 (103.2–119.3.2.3)

0.17

Serum Phosphorus

mg/dL

4.9 (4.3–5.3)

4.4 (3.8–4.9)

0.02

Serum Potassium

mmol/L

4.5 (4.2–4.8)

4.4 (4.1–4.6)

0.49

Serum Sodium

mmol/L

134 (132.8–142.3.8.3)

136 (132.3–138.8.3.8)

0.68

Glucose

mg/dL

88.5 (79.7–95.2)

94 (84.5–102.5.5.5)

0.09

Serum Calcium

mg/dL

9.6 (9.3–10.1)

9.4 (9.2–9.7)

0.10

Osmolality

mOsm/kg

284.2 (280.9–299.2.9.2)

288.7 (281.2–294.9.2.9)

0.84

White Blood Cells

cells/mm3

7620 (7070–9148)

6295 (4833–9198)

0.12

Red Blood Cells

x106/mm3

5.0 (4.7–5.1)

4.8 (4.4–5.2)

0.32

Hemoglobin

g/dL

14.2 (13.7–14.9)

13.7 (13.1–15.10)

0.54

MCV

fL

86.4 (84.4–89)

89.2 (85.3–91.5)

0.16

MCH

pg

28.9 (27.9–29.6)

29.3 (28.4–30.4)

0.22

MCHC

g/dL

33.1 (32.7–33.9)

33.3 (32.1–34.1)

0.86

Platelet count

x103/mm3

267.5 (214–300.3.3)

268.5 (236.5–312.3.5.3)

0.65

Neutrophil count

cells/mm3

4163 (3249–4877)

3752 (2262–5234)

0.32

Lymphocyte count

cells/mm3

2481 (1954–2913)

1718 (1183–2434)

0.001

Monocyte count

cells/mm3

938.5 (732–1044)

934.3 (644.3–1141)

0.87

Eosinophil count

cells/mm3

194.5 (115.3–347.9.3.9)

49.4 (11.9–138.5.9.5)

< 0.001

Basophil count

cells/mm3

51.9 (25.9–68.8)

50 (23–88)

0.75

Androsterone

ng/mL

2388 (1767–3598)

1721 (845.4–2218)

0.003

Etiocholanolone

ng/mL

3259 (2013–5027)

2394 (1642–2946)

0.01

5α-androstanediol

ng/mL

56.6 (38.4–92.7)

48.3 (26.4–68.2)

0.11

5ß-androstanediol

ng/mL

327.5 (204.5–548.9.5.9)

306.5 (233–367.9.9)

0.37

Epitestorone

ng/mL

21.8 (15.1–31.8)

11.7 (7.6–18.3)

< 0.001

Testosterone

ng/mL

23 (14.7–34.7)

16.6 (8.4–22.3)

0.05

  1. Data represent medians and interquartile ranges. The Mann-Whitney test was used to compare the distributions of the plasma mediators between the study groups. P-values in bold font are statistically significant. Participants were classified as Moderate Muscular Response (CK < 1000 U/L) or Exacerbated Muscular Response (CK ≥ 1000 U/L). Abbreviations: ALT = Alanine Aminotransferase, AST = Aspartate Aminotransferase, CK = Creatine Kinase, CKMB = Creatine Kinase Muscle-Brain, GFR = Glomerular Filtration Rate, GGT = Gamma-Glutamyl Transferase, LDH = Lactate Dehydrogenase, MCH = Mean Corpuscular Hemoglobin, MCHC = Mean Corpuscular Hemoglobin Concentration, MCV = Mean Corpuscular Volume.
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