Fig. 1

Restricted cubic splines describing the non-linear association between body mass index (BMI) and pathological complete response (pCR) in HER2-positive breast cancer patients receiving neoadjuvant targeted therapy. Odds ratios (OR) are based on logistic regression adjusted for age, clinical T stage, node status, hormone receptor status, HER2 staining intensity, Ki-67, neoadjuvant chemotherapy regimen and targeted therapy.