Table 2 Performance metrics for each cut off value of NLR for diagnosis PV.

From: Low neutrophil-to-lymphocyte ratio identifies secondary polycythemia in patients with erythrocytosis

 

Subnormal EPO

1.5

p value

2.97

p value

4.5

p value

Sensitivity

0.719 (0.642–0.787)

0.988 (0.956–0.999)

< 0.001

0.856 (0.792–0.907)

0.005

0.588 (0.507–0.665)

0.019

Specificity

0.951 (0.927–0.968)

0.332 (0.290–0.376)

< 0.001

0.852 (0.817–0.882)

< 0.001

0.963 (0.942–0.978)

0.405

PPV

0.827 (0.754–0.886)

0.328 (0.286–0.372)

< 0.001

0.656 (0.587–0.720)

< 0.001

0.839 (0.758–0.902)

0.935

NPV

0.911 (0.883–0.934)

0.988 (0.956–0.999)

0.002

0.947 (0.922–0.966)

0.044

0.876 (0.845–0.903)

0.086

AUC

0.835 (0.798–0.871)

0.660 (0.637–0.682)

< 0.001

0.854 (0.822–0.885)

0.434

0.775 (0.736–0.814)

0.028

  1. AUC area under the ROC curve, EPO erythropoietin, NPV negative predictive value, PPV positive predictive value.
  2. *p value is compared to subnormal EPO.
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