Fig. 1: Methimazole treatment induces HTX in pregnant mice | Scientific Reports

Fig. 1: Methimazole treatment induces HTX in pregnant mice

From: Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring

Fig. 1: Methimazole treatment induces HTX in pregnant mice

Total thyroid hormones and TSH levels were measured in serum samples from EUT (euthyroid), HTX (methimazole-treated), and HTX + T4 (methimazole + T4-supplemented) dams at embryonic day 14 (E14) (see Materials and Methods). (a) Total T4 (tT4), (b) Total T3 (tT3), and (c) TSH levels. n = 11 pregnant mice per group. Data are presented as mean ± SEM. Statistical significance was determined by using one-way ANOVA with Tukey’s post hoc test or Kruskal–Wallis test with Dunn’s post hoc test, depending on data normality. ***p ≤ 0.001, ****p ≤ 0.0001. EUT: white box; HTX: red box; HTX + T4: green box.

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