Fig. 1 | Scientific Reports

Fig. 1

From: Single-cell and bulk transcriptomics reveal Fusobacterium nucleatum promotes colorectal cancer metastasis by upregulating LAMC2 in in vitro and in vivo models

Fig. 1

F. nucleatum promotes the migration of CRC cells in vitro. (A) Scanning electron microscopy and (B) transmission electron microscopy images show rod-shaped bacteria (arrows) penetrating and invading HCT116 cells. (C-J) LOVO and HCT116 cells were incubation with PBS control, E.coli, or F. nucleatum. Cell migration ability was evaluated through wound healing assays and Transwell assays (n = 4 per group, One-way ANOVA test). In the Transwell assays, migrated cells were stained with crystal violet, and images were randomly captured under a microscope, with 5 random fields per sample counted. Statistical analysis was performed using one-way ANOVA. Data are shown as mean ± SD.* represents p < 0 0.05, ** represents p < 0 0.01, *** represents p < 0.001, and **** represents p < 0.0001, ns represents no statistical significant.

Back to article page