Fig. 1 | Scientific Reports

Fig. 1

From: People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor exhibit worse pulmonary function and pro-inflammatory airway milieu

Fig. 1

PwCF taking ETI had lower NE activity driven by an activity low (NELo) sub-population. (A) NE activity in sputum supernatant was significantly lower in pwCF taking ETI than in those with no HEMT, owing to an activity low sub-population. The cutoff of 400 ng/mL activity, delineating NEHi and NELo subpopulations, is marked with a dashed line. n = 30 pwCF on ETI and n = 9 taking no HEMT. (B) MPO activity in sputum supernatant was not statistically significant between the two groups. Statistical significance is derived from Mann-Whitney test. n = 25 pwCF on ETI and n = 9 taking no HEMT.

Back to article page