Fig. 2 | Scientific Reports

Fig. 2

From: People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor exhibit worse pulmonary function and pro-inflammatory airway milieu

Fig. 2

PwCF taking ETI with high NE activity have higher sputum MPO activity and pro-inflammatory cytokine burden, and lower CXC chemokines. (A) MPO activity significantly differed between NEHi and NELo subpopulations (n = 14 and n = 11, respectively). P-value shown is from Mann-Whitney test. (B-M) Twelve immune mediators assayed using Mesoscale or ELISA assay that were significantly different between NEHi and NELo subpopulations. All data are presented as median with interquartile range, with individual data points. P-values shown are from Mann-Whitney tests. Results also passed q < 0.05 thresholding based on the Benjamini-Hochberg test for multiple comparisons. n = 17 pwCF NEHi and n = 13 NELo, except for IL-8 (n = 16 NEHi and n = 11 NELo).

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