Fig. 3 | Scientific Reports

Fig. 3

From: People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor exhibit worse pulmonary function and pro-inflammatory airway milieu

Fig. 3

Metabolomics reveals broad differences between NEHi and NELo subjects with strong evidence of higher neutrophilic involvement in NEHi subjects. (A) Heatmap of 107 metabolites selected by Mann-Whitney test controlled by Benjamini-Hochberg correction of p-values (p < 0.05, q < 0.05). Column (sample) and row (metabolite) data are clustered using Ward clustering with Euclidean distance, and columns are Z-scored. n = 12 NEHi and n = 10 NELo pwCF on ETI. (B) Pathway analysis of significant metabolites. Pathways that are p < 0.05 and q < 0.05 are named. (D-F) Significant metabolites selected from important pathways and/or associated with pathological processes are shown in grouped barplots. For all barplots, individual data points are shown over bars of median and interquartile ranges.

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