Table 4 Cox proportional hazards regression analysis of PFS and OS in all patients.

From: Correlation analysis between RAS gene mutations and pathological morphological features in colorectal cancer

Characteristic

OS

PFS

Univariate analysis HR (95% CI)

P-value

Multivariate analysis HR (95% Cl)

P-value

Univariate analysis HR (95% Cl)

P-value

Multivariateanalysis HR (95% Cl)

P-value

TP53

Wild type

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Mutant

1.30 (0.95–1.78)

0.102

1.15(0.81–1.62)

0.437

1.25 (0.92–1.70)

0.156

1.10 (0.78–1.55)

0.582

APC

Wild type

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Mutant

0.90 (0.65–1.25)

0.525

0.95 (0.67–1.36)

0.78

0.85 (0.62–1.16)

0.303

0.92 (0.65–1.30)

0.634

PIK3CA

Wild type

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Mutant

1.45 (1.00-2.10)

0.049*

1.25 (0.85–1.85)

0.254

1.35 (0.97–1.88)

0.078

1.20 (0.85–1.70)

0.298

Age

<60 years

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

≥ 60 years

1.20 (0.88–1.65)

0.251

1.10 (0.79–1.53)

0.571

 

1.15 (0.85–1.56)

0.367

0.781

Gender

Male

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Female

0.90 (0.66–1.23)

0.502

0.85 (0.61–1.19)

0.343

0.95 (0.70–1.30)

0.742

0.88 (0.63–1.23)

0.457

Tumor location

Left-sided colon

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Right-sided colon

1.45 (0.95–2.20)

0.083

1.25 (0.80–1.95)

0.328

1.30 (0.87–1.94)

0.201

1.15 (0.76–1.75)

0.504

Rectum

1.15 (0.73–1.82)

0.546

1.00 (0.62–1.62)

0.996

1.10 (0.72–1.68)

0.661

0.95 (0.61–1.48)

0.823

TNM stage

Stage I

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Stage II–III

2.50 (1.40–4.46)

0.002*

2.05 (1.12–3.75)

0.020*

2.20 (1.30–3.72)

0.003*

1.85 (1.08–3.17)

0.025*

Stage IV

6.80 (3.75–12.33)

<0.001*

4.80 (2.55–9.05)

<0.01**

5.72 (3.25–10.07)

<0.001**

4.15 (2.28–7.56)

<0.001**

Tumor differentiation

Well

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

Moderate

1.50 (0.95–2.38)

0.080

1.30 (0.80–2.12)

0.293

1.40 (0.90–2.18)

0.138

1.25 (0.78-2.00)

0.356

Poor

2.40 (1.50–3.85)

<0.001**

2.00 (1.20–3.33)

0.007**

2.10 (1.35–3.25)

0.001*

1.75 (1.10–2.80)

0.018*

MSI/MMR status

MSS/pMMR

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

MSI-H/dMMR

0.40 (0.20–0.80)

0.008*

0.55 (0.27–1.12)

0.098

0.45 (0.25–0.82)

0.009*

0.60 (0.32–1.12)

0.108

Primary tumor resection

Yes

1 (reference)

-

1 (reference)

-

1 (reference)

-

1 (reference)

-

No

4.20 (2.80–6.30)

<0.001**

3.20 (2.05-5.00)

<0.001**

3.50 (2.40–5.10)

<0.001*

2.80 (1.85–4.25)

<0.001*

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