Table 2 Univariate and multivariate Cox regression analysis of 91 EOC patients.
Variables | Cut-Off Value | OS | PFS | ||||
|---|---|---|---|---|---|---|---|
HR | 95%CI | P | HR | 95%CI | P | ||
Age | 60 | ||||||
< 60 | 1.000 | Referent | 1.000 | Referent | |||
≥ 60 | 1.060 | 0.666–1.688 | 0.467 | 1.712 | 1.017–2.883 | 0.043 | |
FIGO stage | |||||||
III | 1.000 | Referent | 1.000 | Referent | |||
IV | 0.581 | 0.251–1.341 | 0.902 | 9.301 | 0.344–2.518 | 0.887 | |
Platinum response | |||||||
Resistant | 1.000 | Referent | 1.000 | Referent | |||
Sensitive | 0.072 | 0.033–0.158 | < 0.001 | ||||
Pathology | |||||||
HGSOC | 1.000 | Referent | 1.000 | Referent | |||
Non-HGSOC | 0.740 | 0.388–1.413 | 0.362 | 5.836 | 0.306–1.114 | 1.102 | |
Tumor residual size | |||||||
R0 | 1.000 | Referent | 1.000 | Referent | |||
Non-R0 | 2.056 | 1.057–3.994 | 0.034 | 2.539 | 1.363–4.730 | 0.003 | |
PFI | |||||||
< 6 months | 6 | 1.000 | Referent | 1.000 | Referent | ||
≥ 6 months | 0.204 | 0.054–0.772 | 0.019 | 8.072 | 0.020–0.327 | < 0.001 | |
CD8+count | 79 | ||||||
≤ 79 | 1.000 | Referent | 1.000 | Referent | |||
> 79 | 1.236 | 0.622–2.459 | 0.545 | 1.516 | 0.761–3.021 | 0.236 | |
CD39+ count | 804 | ||||||
≤ 804 | 1.000 | Referent | 1.000 | Referent | |||
> 804 | 0.712 | 0.444–1.141 | 0.327 | 4.971 | 0.186–1.326 | 0.163 | |
CD39+CD8+count | 31 | ||||||
≤ 31 | 1.000 | Referent | 1.000 | Referent | |||
> 31 | 1.305 | 0.818–2.083 | 0.992 | 5.375 | 0.183–1.580 | 0.259 | |
CD39+ in CK+ region count | 1.78 | ||||||
≤ 1.78 | 1.000 | Referent | 1.000 | Referent | |||
> 1.78 | 0.435 | 0.214–1.883 | 0.121 | 1.082 | 0.414–2.832 | 0.872 | |
CD39+ in CK− region count | 800.97 | ||||||
≤ 800.97 | 1.000 | Referent | 1.000 | Referent | |||
> 800.97 | 0.587 | 0.355–0.972 | 0.038 | 1.325 | 0.487–3.605 | 0.581 | |
CD8+ T cells in CK+ region | 67 | ||||||
≤ 67 | 1.000 | Referent | 1.000 | Referent | |||
> 67 | 1.167 | 0.732–2.706 | 0.698 | 1.257 | 0.592–2.669 | 0.552 | |
CD8+T cells in CK− region | 1 | ||||||
≤ 1 | 1.000 | Referent | 1.000 | Referent | |||
> 1 | 1.555 | 0.796–3.035 | 0.196 | 1.337 | 0.595–3.004 | 0.482 | |
CD39+CD8+ T cells in CK+ region | 20 | ||||||
≤ 20 | 1.000 | Referent | 1.000 | Referent | |||
> 20 | 1.429 | 0.883–2.311 | 0.510 | 7.245 | 0.251–2.094 | 0.552 | |
CD39+CD8+ T cells in CK− region | 18 | ||||||
≤ 18 | 1.000 | Referent | 1.000 | Referent | |||
> 18 | 0.458 | 0.272–0.769 | 0.003 | 1.098 | 0.579–2.081 | 0.775 | |
