Table 2 Cannabinoid concentrations (ng/g) in liver, kidney, muscle and adipose tissue of male Holstein cattle administered industrial hemp inflorescence at 4.2 mg/kg Cannabidiolic acid (CBDA) per day for 14 days.

From: Tissue residue depletion of cannabinoids in cattle administered industrial hemp inflorescence

Analyte2

Day after last dose1

1

2

3

5

8

Liver

Mean3

SEM

Mean3

SEM

Mean3

SEM

Mean3

SEM

Mean3

SEM

9-THC

3.25

0.79

2.66

1.01

N/D

N/D

0.41

0.41

N/D

N/D

THCA

61.18

12.82

25.98

5.42

7.58

2.67

5.24

2.54

1.5

N/A

THC-acid-glu

0.48

0.48

N/D

N/D

3.49

2.11

0.65

0.65

2.27

2.27

THC-glu

11.20

2.69

3.98

1.48

1.16

0.68

0.86

0.86

N/D

N/D

CBD

23.00

6.22

16.42

4.27

1.75

0.72

2.32

1.62

0.37

0.37

CBDA

37,340

24,740

4,377

1,971

966.1

465.6

1,131

1,087

11.28

7.17

CBDVA

12.25

1.30

2.96

1.07

N/D

N/D

0.62

0.62

N/D

N/D

CBLA

16.25

7.51

2.34

2.34

1.27

0.76

0.32

0.32

N/D

N/D

CBD-7-acid

135.6

31.61

225.5

57.46

93.14

16.37

128.2

60.68

49.38

8.39

Kidney

          

8-THC

5.10

0.46

3.35

1.46

1.35

0.99

N/D

N/D

N/D

N/D

9-THC

7.65

1.02

7.02

2.60

4.67

1.88

0.66

0.39

1.69

0.57

THCA

7.80

1.18

4.39

0.79

1.11

0.38

N/D

N/D

N/D

N/D

THC-acid

20.83

7.20

28.55

5.19

20.73

4.81

5.18

5.18

N/D

N/D

CBD

9.27

1.86

11.55

4.70

7.96

3.46

1.84

0.66

3.15

1.10

CBDA

10.56

2.64

6.29

1.07

1.67

1.05

N/D

N/D

0.41

0.41

Muscle

          

THC-acid

1.48

0.16

4.95

1.06

2.91

0.53

3.93

1.64

1.77

0.38

CBD

1.42

0.51

2.11

0.37

1.52

0.88

N/D

N/D

1.75

1.75

CBDA

18.79

6.36

7.96

2.31

2.97

2.17

N/D

N/D

0.34

0.34

CBD-7-acid

14.49

1.23

25.71

7.42

21.29

3.82

13.96

3.85

8.82

1.36

Adipose

          

9-THC

46.76

3.58

59.08

6.13

43.79

4.31

43.74

3.99

28.06

5.87

CBD

223.4

25.66

287.1

32.45

203.7

35.29

243.8

38.25

142.9

44.33

CBDA

33.02

12.09

11.88

8.49

N/D

N/D

N/D

N/D

N/D

N/D

CBD-7-acid

79.38

27.35

115.4

49.59

105.1

13.34

53.73

15.57

54.65

18.44

  1. 1‘Day after last dose’ indicates the timepoints for humane euthanasia and tissue collection. 2 8-THC: Δ8-tetrahydrocannabinol; 9-THC: Δ9-tetrahydrocannabinol; THCA: Δ9-tetrahydrocannabinolic acid A; THC-acid: (−)−11-nor-9-carboxy-Δ9-tetrahydrocannabinol; THC-acid-glu: (+)−11-nor-9-carboxy-Δ9-tetrahydrocannabinol glucuronide; THC-glu: Δ9-tetrahydrocannabinol glucuronide; CBD: cannabidiol; CBD-7-acid: (−)−7-nor-7-carboxy cannabidiol; CBLA: cannabicyclolic acid; CBDVA: cannabidivarinic acid. 3Mean of the four replicates (animals) from that day. Values < LLOQ but > LOD were included unchanged and samples with undetectable levels were included as ‘0’. N/D – not detected in any replicates (animals) from that day; N/A – not applicable.
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