Table 5 Exposure estimates in males for Δ9-tetrahydrocannabinol (9-THC) and Cannabidiol (CBD) in beef fat from cattle administered industrial hemp inflorescence.

From: Tissue residue depletion of cannabinoids in cattle administered industrial hemp inflorescence

  

Cannabinoid intake3

Allowable exposure4

Intake/allowable5

Age

BW1

Fat intake2

9-THC

CBD

9-THC

CBD

9-THC

CBD

y

kg

g/d

ng/d

ng/d

µg

µg

%

%

Newborn

3.41

79

5,900

29,300

3.41

512

173

5.72

0.5

8.41

79

5,900

29,300

8.41

1,260

70.2

2.33

1

10.59

125

9,340

46,400

10.6

1,590

88.1

2.92

1.5

12.07

125

9,340

46,400

12.1

1,810

77.2

2.56

2–3

13.14

121

9,040

44,900

14.0

2,100

64.6

2.14

3–6

16.6

136

10,200

50,500

16.6

2,490

61.4

2.03

6–11

23.9

168

12,500

62,300

23.9

3,580

52.3

1.74

11–16

46.5

223

16,700

82,700

46.5

6,970

35.9

1.19

16–21

71.3

278

20,800

103,000

71.3

10,700

29.2

0.963

21–31

85.5

254

19,000

94,200

85.5

12,800

22.2

0.736

31–41

94.4

352

26,300

131,000

94.4

14,200

27.9

0.923

41–51

93.9

218

16,300

80,900

93.9

14,100

17.4

0.574

51–61

91.9

214

16,000

79,400

91.9

13,800

17.4

0.575

61–71

91.2

197

14,700

73,100

91.2

13,700

16.1

0.534

71–81

87.7

144

10,800

53,400

87.7

13,200

12.3

0.405

81+

80.5

137

10,200

50,800

80.5

12,100

12.7

0.420

  1. 1Body weight (BW) values represent means for each sex and age group and were retrieved from the Centers for Disease Control (CDC), with most values extracted from anthropometric data from 2015-2018 and values for newborn through 2 y extracted from the most recent growth charts (2000)36,37. Where ages did not align with the fat intake groups, the BW associated with the youngest age for the intake range was used. For ages 21+, the BW of the most similar age group to the fat intake age group was used (e.g. for the 31–41 y intake group, BW from 30–39 y was used). 2Fat intake data (95th percentiles within males and females) of each age group were retrieved from Tables 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 and 38 of the 2018 Environmental Protection Agency Exposure Factors Handbook representing the top decile of animal fat consumers35. For age ranges 71–81 y and 81+ y, separate data were not available for males and females. 3Intake was calculated as (Fat intake in g/d) × (9-THC or CBD concentration in ng/g). Concentrations of 9-THC and CBD were the upper 99% CI from the day with the highest 9-THC or CBD concentrations in cattle adipose tissue (day 2): 74.7 ng/g and 371 ng/g, respectively. 4The allowable 9-THC exposure (1 µg/kg/d) is from the acute reference dose (ARfD) published by the European Food Safety Authority (EFSA)9. The allowable CBD exposure (0.15 mg/kg/d = 150 µg/kg/d) is from the acceptable daily intake (ADI) published by the Food Standards Agency (FSA)10. 5Intake/allowable was calculated as [(ng intake of 9-THC) ÷ 1,000 ng/µg)] ÷ (µg allowable exposure of 9-THC) × 100% and [(ng intake of CBD) ÷ 1,000 ng/µg)] ÷ (µg allowable exposure of CBD) × 100%.
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